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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Caur_2634
OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Taxonomic identifieri324602 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
Proteomesi
  • UP000002008 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000876491 – 572Formate--tetrahydrofolate ligaseAdd BLAST572

Interactioni

Protein-protein interaction databases

STRINGi324602.Caur_2634.

Structurei

3D structure databases

ProteinModelPortaliA9WIW3.
SMRiA9WIW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
HOGENOMiHOG000040280.
InParanoidiA9WIW3.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiPOG091H01S8.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiView protein in InterPro
IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01268. FTHFS. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A9WIW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTSLQIAAE ARLEPIAAIA ERLGLPVRYL EPYGRYRGKI DLTFLDDYHD
60 70 80 90 100
RPLGRYVLVS AITPTPLGEG KTTTAIGLAM ALNRIGKRAA VTLRQSSLGP
110 120 130 140 150
VFGIKGGGAG GGYSQIVPLV ESILHLNGDI HAVSQAHNQL AALTDNSWYH
160 170 180 190 200
GNPLDIDPDR IEIRRVVDVN DRFLRQVMIG LGGKQNGFPR QTGFDISVAS
210 220 230 240 250
ELMAILAMVN GVGARAALRD LRSRIGRMVV AFRRDGTPIT AEDVRGAGAA
260 270 280 290 300
TVLMREALKP NLMQTIENTP ALIHAGPFAN IAQGNSSILA DLIALRCADY
310 320 330 340 350
VVTEAGFGVD IGAEKFFNLK CRASGLWPDV AVIVATIRAL KAHSGKYDIV
360 370 380 390 400
AGKPLPPALL HENPDDVISG GANLRRQIEN LHQFKVPVIV ALNAYPEDTP
410 420 430 440 450
AEIDAVAHIA TTAGAAGMAV SNVYAAGSAG GVDLARLVIE IAERPGPRPV
460 470 480 490 500
QFLYPLEWSL ADKITTIAHR IYGAAAVTFS PTAAAQLAAL EDAGFGNLPI
510 520 530 540 550
CMAKTHLSLS HDPALRGAPE GFTFPIREVR LSAGAGFILP IAGTTVTMPG
560 570
LGAHPAAHQI DIDDEGNIVG LF
Length:572
Mass (Da):60,580
Last modified:February 5, 2008 - v1
Checksum:i25EFDFB2BF369EF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA. Translation: ABY35840.1.
RefSeqiWP_012258493.1. NC_010175.1.
YP_001636229.1. NC_010175.1.

Genome annotation databases

EnsemblBacteriaiABY35840; ABY35840; Caur_2634.
GeneIDi5827104.
KEGGicau:Caur_2634.
PATRICifig|324602.8.peg.2969.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFTHS_CHLAA
AccessioniPrimary (citable) accession number: A9WIW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: June 7, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families