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A9WIW3

- FTHS_CHLAA

UniProt

A9WIW3 - FTHS_CHLAA

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCAUR324602:GIXU-2679-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Caur_2634
OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Taxonomic identifieri324602 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
ProteomesiUP000002008: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Formate--tetrahydrofolate ligasePRO_1000087649Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi324602.Caur_2634.

Structurei

3D structure databases

ProteinModelPortaliA9WIW3.
SMRiA9WIW3. Positions 5-570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
InParanoidiA9WIW3.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9WIW3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTSLQIAAE ARLEPIAAIA ERLGLPVRYL EPYGRYRGKI DLTFLDDYHD
60 70 80 90 100
RPLGRYVLVS AITPTPLGEG KTTTAIGLAM ALNRIGKRAA VTLRQSSLGP
110 120 130 140 150
VFGIKGGGAG GGYSQIVPLV ESILHLNGDI HAVSQAHNQL AALTDNSWYH
160 170 180 190 200
GNPLDIDPDR IEIRRVVDVN DRFLRQVMIG LGGKQNGFPR QTGFDISVAS
210 220 230 240 250
ELMAILAMVN GVGARAALRD LRSRIGRMVV AFRRDGTPIT AEDVRGAGAA
260 270 280 290 300
TVLMREALKP NLMQTIENTP ALIHAGPFAN IAQGNSSILA DLIALRCADY
310 320 330 340 350
VVTEAGFGVD IGAEKFFNLK CRASGLWPDV AVIVATIRAL KAHSGKYDIV
360 370 380 390 400
AGKPLPPALL HENPDDVISG GANLRRQIEN LHQFKVPVIV ALNAYPEDTP
410 420 430 440 450
AEIDAVAHIA TTAGAAGMAV SNVYAAGSAG GVDLARLVIE IAERPGPRPV
460 470 480 490 500
QFLYPLEWSL ADKITTIAHR IYGAAAVTFS PTAAAQLAAL EDAGFGNLPI
510 520 530 540 550
CMAKTHLSLS HDPALRGAPE GFTFPIREVR LSAGAGFILP IAGTTVTMPG
560 570
LGAHPAAHQI DIDDEGNIVG LF
Length:572
Mass (Da):60,580
Last modified:February 5, 2008 - v1
Checksum:i25EFDFB2BF369EF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA. Translation: ABY35840.1.
RefSeqiYP_001636229.1. NC_010175.1.

Genome annotation databases

EnsemblBacteriaiABY35840; ABY35840; Caur_2634.
GeneIDi5827104.
KEGGicau:Caur_2634.
PATRICi21416447. VBIChlAur28763_2969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA. Translation: ABY35840.1 .
RefSeqi YP_001636229.1. NC_010175.1.

3D structure databases

ProteinModelPortali A9WIW3.
SMRi A9WIW3. Positions 5-570.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 324602.Caur_2634.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY35840 ; ABY35840 ; Caur_2634 .
GeneIDi 5827104.
KEGGi cau:Caur_2634.
PATRICi 21416447. VBIChlAur28763_2969.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
InParanoidi A9WIW3.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CAUR324602:GIXU-2679-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29366 / DSM 635 / J-10-fl.

Entry informationi

Entry nameiFTHS_CHLAA
AccessioniPrimary (citable) accession number: A9WIW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3