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Reviewed, UniProtKB/Swiss-Prot A9WIS6 (DCUP_CHLAA)

Last modified February 9, 2010. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37
Gene names
Name: hemE
Ordered Locus Names: Caur_2597
OrganismChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) [Complete proteome] [HAMAP]
Taxonomic identifier324602 [NCBI]
Taxonomic lineageBacteria › Chloroflexi › Chloroflexales › Chloroflexaceae › Chloroflexus

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Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

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Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_1000078068

Regions

Region23 – 275Substrate binding By similarity

Sites

Binding site721Substrate By similarity
Binding site1481Substrate By similarity
Binding site2031Substrate By similarity
Binding site3211Substrate By similarity
Site721Transition state stabilizer By similarity

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Sequences

Sequence LengthMass (Da)Tools
A9WIS6-1 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 1B39A682E15DE5B8

FASTA35539,488
        10         20         30         40         50         60 
MRDRFLRACR RQPVDRTPIW LMRQAGRYMP EYRAIRERYG FLQMVKTPEV AAEVTLQPVQ 

        70         80         90        100        110        120 
AFGVDAAIIF ADILPPLEGL GLQLTYEKGE GPVIHNPIRS PHDVSVLRSC DPRETVAYTL 

       130        140        150        160        170        180 
AALQLVKREL NGLPLIGFSG APFTLASYAI EGGGSREYRL TKRFMYEQPA AWHDLMERLS 

       190        200        210        220        230        240 
RLVADYLIAQ IEAGADAVQI FDSWAGALSP ADYRAYVLRH TQALVQTIRA RLGDVTPPII 

       250        260        270        280        290        300 
YFGTDMAGLA GEVRQIGADV LGVDWRIDLD VAWAQYGFNH AVQGNLDPMT LFAPPSIIAA 

       310        320        330        340        350 
RARDILERAG GRPGHIFNLG HGILTETPVD HVRYLVEFVQ SYPLPATAPV LQEVV

« Hide

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References

[1]"Complete sequence of Chloroflexus aurantiacus J-10-fl."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Pierson B.K., Blankenship R.E., Richardson P.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000909 Genomic DNA. Translation: ABY35803.1.
RefSeqYP_001636192.1.

3D structure databases

SMRA9WIS6. Positions 1-343.
ModBaseSearch...

Genome annotation databases

GeneID5827066.
GenomeReviewsGene locus Caur_2597 in contig CP000909_GR.
KEGGcau:Caur_2597.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG628392.
OMAQIFDTWG.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. hemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDCUP_CHLAA
AccessionPrimary (citable) accession number: A9WIS6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: February 9, 2010
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents