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A9WHH4

- TRMB_CHLAA

UniProt

A9WHH4 - TRMB_CHLAA

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, Caur_3101
Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571S-adenosyl-L-methionine By similarity
Binding sitei82 – 821S-adenosyl-L-methionine By similarity
Binding sitei109 – 1091S-adenosyl-L-methionine By similarity
Binding sitei167 – 1671Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCAUR324602:GIXU-3150-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:Caur_3101
OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Taxonomic identifieri324602 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
ProteomesiUP000002008: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000387942Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi324602.Caur_3101.

Structurei

3D structure databases

ProteinModelPortaliA9WHH4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000033410.
KOiK03439.
OMAiRLVNREF.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9WHH4-1 [UniParc]FASTAAdd to Basket

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MGRGRYPARL YVTAPPPEIA ARYYRSWPAK ELYHTPEHFP PVSAEGLFGY    50
NAPLTLEFGC ATGEYLCALA AAQPSSCFVG IDIVAKPLYR AVERAVAGNL 100
SNILFIHADA RLIYQRIPTA ALHSIILHFP PPLLRNRQRN QLLVSPQLLE 150
CAARTLVPGG YLSFLTDHPA LFALMQELLP AFPALRATPA SVEELAVFES 200
HYHRRWAARG RTISGLRIER VMED 224
Length:224
Mass (Da):24,960
Last modified:February 5, 2008 - v1
Checksum:iA30622F44EFDBF20
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000909 Genomic DNA. Translation: ABY36300.1.
RefSeqiYP_001636689.1. NC_010175.1.

Genome annotation databases

EnsemblBacteriaiABY36300; ABY36300; Caur_3101.
GeneIDi5827575.
KEGGicau:Caur_3101.
PATRICi21417531. VBIChlAur28763_3505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000909 Genomic DNA. Translation: ABY36300.1 .
RefSeqi YP_001636689.1. NC_010175.1.

3D structure databases

ProteinModelPortali A9WHH4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 324602.Caur_3101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY36300 ; ABY36300 ; Caur_3101 .
GeneIDi 5827575.
KEGGi cau:Caur_3101.
PATRICi 21417531. VBIChlAur28763_3505.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000033410.
KOi K03439.
OMAi RLVNREF.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci CAUR324602:GIXU-3150-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29366 / DSM 635 / J-10-fl.

Entry informationi

Entry nameiTRMB_CHLAA
AccessioniPrimary (citable) accession number: A9WHH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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