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A9WHA3

- A9WHA3_CHLAA

UniProt

A9WHA3 - A9WHA3_CHLAA

Protein

3-oxoacyl-[acyl-carrier-protein] synthase 3

Gene

fabH

Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei116 – 1161UniRule annotation
    Active sitei256 – 2561UniRule annotation
    Active sitei286 – 2861UniRule annotation

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
    2. beta-ketoacyl-acyl-carrier-protein synthase III activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciCAUR324602:GIXU-2445-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 3UniRule annotation (EC:2.3.1.180UniRule annotation)
    Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase IIIUniRule annotation
    Beta-ketoacyl-ACP synthase IIIUniRule annotation
    Gene namesi
    Name:fabHUniRule annotation
    Ordered Locus Names:Caur_2406Imported
    OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)Imported
    Taxonomic identifieri324602 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
    ProteomesiUP000002008: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi324602.Caur_2406.

    Structurei

    3D structure databases

    ProteinModelPortaliA9WHA3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni257 – 2615ACP-bindingUniRule annotation

    Domaini

    The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.UniRule annotation

    Sequence similaritiesi

    Belongs to the FabH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0332.
    HOGENOMiHOG000246674.
    KOiK00648.
    OMAiIRIMEAA.
    OrthoDBiEOG6J74XN.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    HAMAPiMF_01815. FabH.
    InterProiIPR013751. ACP_syn_III.
    IPR013747. ACP_syn_III_C.
    IPR004655. FabH_synth.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF08545. ACP_syn_III. 1 hit.
    PF08541. ACP_syn_III_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53901. SSF53901. 1 hit.
    TIGRFAMsiTIGR00747. fabH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9WHA3-1 [UniParc]FASTAAdd to Basket

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    MSRERYAAVI GWGMAVPQRL ITNDELAQRI DTSDEWIRTR TGIRERRVAG    50
    PGESTSTLAT AAGREALTMA GVSPATIDTV IVATCTPDRP FPATACTVQA 100
    NLQIPRATAF DLAAACSGFV YGLTVATSLI KSGVSRRLLL IGADIFTHYI 150
    NWNDRNTCVL FGDGAGAVVL EATDEPLGLL ASTLSANGEL EDLMAVDAGG 200
    TRMPLTADLL EAGRQYVYMN GREIFKHAVR EMSDSALQVI QDAGLTVDDI 250
    ALVIPHQANV RIIDAVARRL EIPPERVMVN LDRYGNTSAA SIPIALYEAA 300
    QQERIKAGDN VLLTAFGGGL TWGSGLVRWG KPSR 334
    Length:334
    Mass (Da):35,770
    Last modified:February 5, 2008 - v1
    Checksum:i46930E1BAB0DE50C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000909 Genomic DNA. Translation: ABY35615.1.
    RefSeqiYP_001636004.1. NC_010175.1.

    Genome annotation databases

    EnsemblBacteriaiABY35615; ABY35615; Caur_2406.
    GeneIDi5826870.
    KEGGicau:Caur_2406.
    PATRICi21415937. VBIChlAur28763_2720.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000909 Genomic DNA. Translation: ABY35615.1 .
    RefSeqi YP_001636004.1. NC_010175.1.

    3D structure databases

    ProteinModelPortali A9WHA3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 324602.Caur_2406.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY35615 ; ABY35615 ; Caur_2406 .
    GeneIDi 5826870.
    KEGGi cau:Caur_2406.
    PATRICi 21415937. VBIChlAur28763_2720.

    Phylogenomic databases

    eggNOGi COG0332.
    HOGENOMi HOG000246674.
    KOi K00648.
    OMAi IRIMEAA.
    OrthoDBi EOG6J74XN.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci CAUR324602:GIXU-2445-MONOMER.

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    HAMAPi MF_01815. FabH.
    InterProi IPR013751. ACP_syn_III.
    IPR013747. ACP_syn_III_C.
    IPR004655. FabH_synth.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF08545. ACP_syn_III. 1 hit.
    PF08541. ACP_syn_III_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53901. SSF53901. 1 hit.
    TIGRFAMsi TIGR00747. fabH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29366 / DSM 635 / J-10-flImported.

    Entry informationi

    Entry nameiA9WHA3_CHLAA
    AccessioniPrimary (citable) accession number: A9WHA3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzymeUniRule annotationSAAS annotation, Reference proteomeImported

    External Data

    Dasty 3