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Protein

Methylthioribose-1-phosphate isomerase

Gene

mtnA

Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).UniRule annotation

Catalytic activityi

S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.UniRule annotation

Pathwayi: L-methionine biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Methylthioribose-1-phosphate isomerase (mtnA)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate, the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891SubstrateUniRule annotation
Sitei157 – 1571Transition state stabilizerUniRule annotation
Binding sitei196 – 1961SubstrateUniRule annotation
Active sitei237 – 2371Proton donorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

BioCyciCAUR324602:GIXU-3074-MONOMER.
UniPathwayiUPA00904; UER00874.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylthioribose-1-phosphate isomeraseUniRule annotation (EC:5.3.1.23UniRule annotation)
Short name:
M1PiUniRule annotation
Short name:
MTR-1-P isomeraseUniRule annotation
Alternative name(s):
S-methyl-5-thioribose-1-phosphate isomeraseUniRule annotation
Gene namesi
Name:mtnAUniRule annotation
Ordered Locus Names:Caur_3025
OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Taxonomic identifieri324602 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
Proteomesi
  • UP000002008 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Methylthioribose-1-phosphate isomerasePRO_0000357160Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi324602.Caur_3025.

Structurei

3D structure databases

ProteinModelPortaliA9WGQ8.
SMRiA9WGQ8. Positions 1-343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 483Substrate bindingUniRule annotation
Regioni247 – 2482Substrate bindingUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C35. Bacteria.
COG0182. LUCA.
HOGENOMiHOG000224730.
InParanoidiA9WGQ8.
KOiK08963.
OMAiFYNPAFD.
OrthoDBiPOG091H022L.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
HAMAPiMF_01678. Salvage_MtnA. 1 hit.
InterProiIPR000649. IF-2B-related.
IPR005251. IF-M1Pi.
IPR011559. Initiation_fac_2B_a/b/d.
IPR027363. M1Pi_N.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00524. eIF-2B_rel. 1 hit.
TIGR00512. salvage_mtnA. 1 hit.

Sequencei

Sequence statusi: Complete.

A9WGQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRTVWWEN DAVCLIDQRK LPHTMEVVRC TDLAAVAYAI RSMQVRGAPA
60 70 80 90 100
IGCTAAYGMA LVAQQSVALT PSALLTELVQ AKATLDSQRP TAVNLAWATS
110 120 130 140 150
RMLRRAEAVA SEGVEAIKHA LHAEAEAIFA EDLAMCHAIG EHGASLIPPR
160 170 180 190 200
GHVLTHCNAG GLATAGYGTA LAPIRTAFAQ GRPVHVFVDE TRPFLQGARL
210 220 230 240 250
TAWELLQAGI PQTLITDNMA AFMMQRGQID CVIVGADRIA ANGDVANKIG
260 270 280 290 300
TYGLAVLARY HNIPFYVAAP SSTIDLATAS GADIPIEERD PAEVTHIAGV
310 320 330 340
AIAPQGVRAA HPAFDVTPNE LVTAIITERG IVRPPYLAAL RQLESGR
Length:347
Mass (Da):36,870
Last modified:February 5, 2008 - v1
Checksum:iBB1167C2AE5F63D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA. Translation: ABY36224.1.
RefSeqiWP_012258877.1. NC_010175.1.
YP_001636613.1. NC_010175.1.

Genome annotation databases

EnsemblBacteriaiABY36224; ABY36224; Caur_3025.
GeneIDi5827499.
KEGGicau:Caur_3025.
PATRICi21417373. VBIChlAur28763_3426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA. Translation: ABY36224.1.
RefSeqiWP_012258877.1. NC_010175.1.
YP_001636613.1. NC_010175.1.

3D structure databases

ProteinModelPortaliA9WGQ8.
SMRiA9WGQ8. Positions 1-343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi324602.Caur_3025.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY36224; ABY36224; Caur_3025.
GeneIDi5827499.
KEGGicau:Caur_3025.
PATRICi21417373. VBIChlAur28763_3426.

Phylogenomic databases

eggNOGiENOG4105C35. Bacteria.
COG0182. LUCA.
HOGENOMiHOG000224730.
InParanoidiA9WGQ8.
KOiK08963.
OMAiFYNPAFD.
OrthoDBiPOG091H022L.

Enzyme and pathway databases

UniPathwayiUPA00904; UER00874.
BioCyciCAUR324602:GIXU-3074-MONOMER.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
HAMAPiMF_01678. Salvage_MtnA. 1 hit.
InterProiIPR000649. IF-2B-related.
IPR005251. IF-M1Pi.
IPR011559. Initiation_fac_2B_a/b/d.
IPR027363. M1Pi_N.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00524. eIF-2B_rel. 1 hit.
TIGR00512. salvage_mtnA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTNA_CHLAA
AccessioniPrimary (citable) accession number: A9WGQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.