A9WG02 (A9WG02_CHLAA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Adenylate kinase 2 HAMAP MF_00235
Short name=AK 2 HAMAP MF_00235
EC=2.7.4.3 HAMAP MF_00235

Alternative name(s):
ATP-AMP transphosphorylase 2 HAMAP MF_00235

Gene names

Name:	adk2 HAMAP MF_00235
Ordered Locus Names:	Caur_2957

Organism

Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) EMBL ABY36156.1

Taxonomic identifier

324602 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Chloroflexales › Chloroflexaceae › Chloroflexus

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth By similarity. HAMAP MF_00235
Catalytic activity	ATP + AMP = 2 ADP. HAMAP MF_00235
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1. HAMAP MF_00235
Subunit structure	Monomer By similarity. HAMAP MF_00235
Subcellular location	Cytoplasm By similarity HAMAP MF_00235.
Domain	Consists of three domains, a large central CORE domain and two small peripheral domains, AMP binding and LID. The LID domain closes over the site of phosphoryl transfer upon ATP binding By similarity. HAMAP MF_00235
Sequence similarities	Belongs to the adenylate kinase family. HAMAP MF_00235

Ontologies

Keywords
Biological process	Nucleotide biosynthesis HAMAP MF_00235
Cellular component	Cytoplasm HAMAP MF_00235
Ligand	ATP-binding HAMAP MF_00235 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00235 EMBL ABY36156.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP adenylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	3 – 11	9	ATP By similarity HAMAP MF_00235
	Nucleotide binding	27 – 55	29	AMP By similarity HAMAP MF_00235

Sequences

	Sequence		Length	Mass (Da)
	A9WG02 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 38B47C88C2CF06B6	FASTA	209	23,020
	10 20 30 40 50 60 MIGPPGAGKT TIAGQLAQVT GMAVIATGQQ LRAEIRAQSA LGRYIEPLLE QGQLAPDSVM 70 80 90 100 110 120 AELMRNWLQR IPIDQDCLLD GYPRSVAQAH MLETILADLG RRVDAVIVLT LDEATIVHRL 130 140 150 160 170 180 SGRRICRRDD GQDITVHIDD TAKIAQCLAR GGTLVQREDD HPDVIRTRLR LYEQETAPVL 190 200 NYYTGRVPVH YVNADQSPAA VVALIRDII

References

[1]

"Complete sequence of Chloroflexus aurantiacus J-10-fl." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Pierson B.K., Blankenship R.E., Richardson P. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29366 / DSM 635 / J-10-fl.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000909 Genomic DNA. Translation: ABY36156.1.
RefSeq	YP_001636545.1. NC_010175.1.
3D structure databases
ProteinModelPortal	A9WG02.
ModBase	Search...
Protein-protein interaction databases
STRING	A9WG02.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5827429.
GenomeReviews	Gene locus Caur_2957 in contig CP000909_GR.
KEGG	cau:Caur_2957.
PATRIC	21417227. VBIChlAur28763_3355.
Phylogenomic databases
HOGENOM	HBG630208.
OMA	EMQKYIL.
PhylomeDB	A9WG02.
ProtClustDB	CLSK973426.
Family and domain databases
HAMAP	MF_00235. Adenylate_kinase_Adk. [Tree]
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01351. Adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A9WG02_CHLAA

Accession

Primary (citable) accession number: A9WG02

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)