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A9WFR6

- PANC_CHLAA

UniProt

A9WFR6 - PANC_CHLAA

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Protein
Pantothenate synthetase
Gene
panC, Caur_2207
Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton donor By similarity
Binding sitei57 – 571Beta-alanine By similarity
Binding sitei57 – 571Pantoate By similarity
Binding sitei149 – 1491Pantoate By similarity
Binding sitei172 – 1721ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 338ATP By similarity
Nucleotide bindingi143 – 1464ATP By similarity
Nucleotide bindingi180 – 1834ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCAUR324602:GIXU-2242-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC
Ordered Locus Names:Caur_2207
OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Taxonomic identifieri324602 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
ProteomesiUP000002008: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Pantothenate synthetaseUniRule annotation
PRO_1000076851Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi324602.Caur_2207.

Structurei

3D structure databases

ProteinModelPortaliA9WFR6.
SMRiA9WFR6. Positions 1-273.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiECPIVRE.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

A9WFR6-1 [UniParc]FASTAAdd to Basket

« Hide

MKVLHTVAEF RQARAAFDVL GFVPTMGYLH QGHLALVEQA RRECPAVAVS    50
IFVNPTQFGP NEDYARYPRD TNRDLALLEA AGVDLVFIPS VEEMYPPGFG 100
TYVIQPAADE VLEGAARPGH FRGVATVVCK LFNIVQPTKS YFGQKDAQQT 150
VVVRQMVRDL NLPVEIVIVP TVREPDGLAL SSRNVYLNAE QRAAAPVLYR 200
ALRTAAERYA AGERDAETLR AVMRSVLAGE PLARPDYVSV AHPLTLRELD 250
RIGADGALLS MAVRFDQVRL IDNWLLEGEG K 281
Length:281
Mass (Da):31,012
Last modified:February 5, 2008 - v1
Checksum:iE7F3A49253D840A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000909 Genomic DNA. Translation: ABY35416.1.
RefSeqiYP_001635805.1. NC_010175.1.

Genome annotation databases

EnsemblBacteriaiABY35416; ABY35416; Caur_2207.
GeneIDi5826667.
KEGGicau:Caur_2207.
PATRICi21415491. VBIChlAur28763_2501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000909 Genomic DNA. Translation: ABY35416.1 .
RefSeqi YP_001635805.1. NC_010175.1.

3D structure databases

ProteinModelPortali A9WFR6.
SMRi A9WFR6. Positions 1-273.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 324602.Caur_2207.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY35416 ; ABY35416 ; Caur_2207 .
GeneIDi 5826667.
KEGGi cau:Caur_2207.
PATRICi 21415491. VBIChlAur28763_2501.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi ECPIVRE.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci CAUR324602:GIXU-2242-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29366 / DSM 635 / J-10-fl.

Entry informationi

Entry nameiPANC_CHLAA
AccessioniPrimary (citable) accession number: A9WFR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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