Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A9WEK8

- PUR9_CHLAA

UniProt

A9WEK8 - PUR9_CHLAA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciCAUR324602:GIXU-2088-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Caur_2058
OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Taxonomic identifieri324602 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
ProteomesiUP000002008: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Bifunctional purine biosynthesis protein PurHPRO_1000076477Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi324602.Caur_2058.

Structurei

3D structure databases

ProteinModelPortaliA9WEK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
InParanoidiA9WEK8.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A9WEK8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIGEERVVRA LMSVYDKTGI VEFAQALHNL GIEIISTGQT QRVLREAGIP
60 70 80 90 100
ALPVSDVTGF PEILDGRVKT LHPAIHAGLL ARRDVPAHMA ELAAHNLQPI
110 120 130 140 150
DLVVVNLYPF AATIARPDVT MAEAQEQIDI GGVALLRAAA KNFPAVLVLV
160 170 180 190 200
DPADYAGVLD GLRAGDVPLS ERQRLAAKAF AHTAEYDATI AAYLRTEPLP
210 220 230 240 250
DVLPLAWRKY QPLRYGENPH QAAALYGDFG AFFHQLHGKE LSYNNILDTA
260 270 280 290 300
AAQELIEEFP ATEAAAVAII KHTNPCGVAI AADLHRAWEA AFATDREAPF
310 320 330 340 350
GGIIAVNRPV DIAFAEAVDE IFSEIIIAPD FAPDALALLR RKKNRRLLQS
360 370 380 390 400
VRPITGADRW QLRSVPGGVL VQEPDHAPLV AEEWRVVTKR APTDAEAAAL
410 420 430 440 450
RFAWRVVKHV KSNAIVYAAH DRTLGIGAGQ MSRVDSSRLA VWKAQQAGID
460 470 480 490 500
LRGSVVASDA LFPFADGVEA AIAAGATAII QPGGSVRDEE VIAAADAAGA
510
AMVFTGRRHF RH
Length:512
Mass (Da):55,050
Last modified:February 5, 2008 - v1
Checksum:iC121A9B88A79E7E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA. Translation: ABY35270.1.
RefSeqiWP_012257924.1. NC_010175.1.
YP_001635659.1. NC_010175.1.

Genome annotation databases

EnsemblBacteriaiABY35270; ABY35270; Caur_2058.
GeneIDi5826513.
KEGGicau:Caur_2058.
PATRICi21415153. VBIChlAur28763_2336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA. Translation: ABY35270.1 .
RefSeqi WP_012257924.1. NC_010175.1.
YP_001635659.1. NC_010175.1.

3D structure databases

ProteinModelPortali A9WEK8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 324602.Caur_2058.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY35270 ; ABY35270 ; Caur_2058 .
GeneIDi 5826513.
KEGGi cau:Caur_2058.
PATRICi 21415153. VBIChlAur28763_2336.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
InParanoidi A9WEK8.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci CAUR324602:GIXU-2088-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29366 / DSM 635 / J-10-fl.

Entry informationi

Entry nameiPUR9_CHLAA
AccessioniPrimary (citable) accession number: A9WEK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3