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A9WEK8 (PUR9_CHLAA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:Caur_2058
OrganismChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) [Reference proteome] [HAMAP]
Taxonomic identifier324602 [NCBI]
Taxonomic lineageBacteriaChloroflexiChloroflexalesChloroflexaceaeChloroflexus

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 512512Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000076477

Sequences

Sequence LengthMass (Da)Tools
A9WEK8 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: C121A9B88A79E7E7

FASTA51255,050
        10         20         30         40         50         60 
MIGEERVVRA LMSVYDKTGI VEFAQALHNL GIEIISTGQT QRVLREAGIP ALPVSDVTGF 

        70         80         90        100        110        120 
PEILDGRVKT LHPAIHAGLL ARRDVPAHMA ELAAHNLQPI DLVVVNLYPF AATIARPDVT 

       130        140        150        160        170        180 
MAEAQEQIDI GGVALLRAAA KNFPAVLVLV DPADYAGVLD GLRAGDVPLS ERQRLAAKAF 

       190        200        210        220        230        240 
AHTAEYDATI AAYLRTEPLP DVLPLAWRKY QPLRYGENPH QAAALYGDFG AFFHQLHGKE 

       250        260        270        280        290        300 
LSYNNILDTA AAQELIEEFP ATEAAAVAII KHTNPCGVAI AADLHRAWEA AFATDREAPF 

       310        320        330        340        350        360 
GGIIAVNRPV DIAFAEAVDE IFSEIIIAPD FAPDALALLR RKKNRRLLQS VRPITGADRW 

       370        380        390        400        410        420 
QLRSVPGGVL VQEPDHAPLV AEEWRVVTKR APTDAEAAAL RFAWRVVKHV KSNAIVYAAH 

       430        440        450        460        470        480 
DRTLGIGAGQ MSRVDSSRLA VWKAQQAGID LRGSVVASDA LFPFADGVEA AIAAGATAII 

       490        500        510 
QPGGSVRDEE VIAAADAAGA AMVFTGRRHF RH 

« Hide

References

[1]"Complete genome sequence of the filamentous anoxygenic phototrophic bacterium Chloroflexus aurantiacus."
Tang K.H., Barry K., Chertkov O., Dalin E., Han C.S., Hauser L.J., Honchak B.M., Karbach L.E., Land M.L., Lapidus A., Larimer F.W., Mikhailova N., Pitluck S., Pierson B.K., Blankenship R.E.
BMC Genomics 12:334-334(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29366 / DSM 635 / J-10-fl.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000909 Genomic DNA. Translation: ABY35270.1.
RefSeqYP_001635659.1. NC_010175.1.

3D structure databases

ProteinModelPortalA9WEK8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING324602.Caur_2058.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABY35270; ABY35270; Caur_2058.
GeneID5826513.
KEGGcau:Caur_2058.
PATRIC21415153. VBIChlAur28763_2336.

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMARAFKTDP.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycCAUR324602:GIXU-2088-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_CHLAA
AccessionPrimary (citable) accession number: A9WEK8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways