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A9WEJ7

- PNP_CHLAA

UniProt

A9WEJ7 - PNP_CHLAA

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi493 – 4931MagnesiumUniRule annotation
Metal bindingi499 – 4991MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCAUR324602:GIXU-2077-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Caur_2047
OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Taxonomic identifieri324602 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
ProteomesiUP000002008: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 755755Polyribonucleotide nucleotidyltransferasePRO_0000329588Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi324602.Caur_2047.

Structurei

3D structure databases

ProteinModelPortaliA9WEJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini560 – 61960KHUniRule annotationAdd
BLAST
Domaini629 – 69870S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
InParanoidiA9WEJ7.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9WEJ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTERNIYSVS AEIAGRTLTL EAGRFAEQAD GAVVARYGDT MLLATVVCAK
60 70 80 90 100
EAREGTDFFP LTVDYEEKMY AVGKIPGNFF KREGRPTTTA ILISRLTDRP
110 120 130 140 150
LRPLFPKGFY NEVQVIITTF SIDMENDPGP LAIIAASAAL CISDIPFAGP
160 170 180 190 200
VGAVQMGHLN GQLVVNPKMN EIADSRLDLV VAGTKDAVLM VEAGAYELTE
210 220 230 240 250
DEMLQAVIDG HAVCKQICDL QEQLVQLCGK PKRPFTPPVV DTSLEEAISA
260 270 280 290 300
WMGDRLRKAV RSPIKQEREA QTEALKAEVI AHFTADEPEE EIANRTKEVT
310 320 330 340 350
KAFEKLLKDE VRNAILDEGI RVDGRALDEI RPISIEVGVI PRVHGSAVFT
360 370 380 390 400
RGQTQVLTIT TLGSPGDEQK VDDLGIETSK RYIHHYNFPP FSTGEVRRIG
410 420 430 440 450
TPRRRDIGHG ALAERSLYAV LPDEKDFPYT IRLVSEVLSS NGSSSMASVC
460 470 480 490 500
GSSLSLMDAG VPIKAPVAGV AMGLITGEDG RWRVLTDIQG LEDALGDMDF
510 520 530 540 550
KVAGTAKGVT GLQMDIKTTG ITYEIMREAF AQARAGRLFI LDKMNEVISA
560 570 580 590 600
PRPELSIYAP RIMTIQIPVD KIGALIGPGG KTIRNICETT GAQIDIEDDG
610 620 630 640 650
RVFITTPDGA AARQAISMIE GLTREAKVGD IFLGKVVSIK PFGAFVNILP
660 670 680 690 700
GKDGMVHVSE LDEKRVENVE DVVSLGDEIN VMVIDIDRTT GKISLSRRAV
710 720 730 740 750
LTGETPEERK AAGAAPRPRP REEQRGGRDE PRSLRDELRG PRREGDRPRP

RRRDD
Length:755
Mass (Da):82,432
Last modified:February 5, 2008 - v1
Checksum:iD293AA822551BDCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA. Translation: ABY35259.1.
RefSeqiYP_001635648.1. NC_010175.1.

Genome annotation databases

EnsemblBacteriaiABY35259; ABY35259; Caur_2047.
GeneIDi5826502.
KEGGicau:Caur_2047.
PATRICi21415129. VBIChlAur28763_2324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA. Translation: ABY35259.1 .
RefSeqi YP_001635648.1. NC_010175.1.

3D structure databases

ProteinModelPortali A9WEJ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 324602.Caur_2047.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY35259 ; ABY35259 ; Caur_2047 .
GeneIDi 5826502.
KEGGi cau:Caur_2047.
PATRICi 21415129. VBIChlAur28763_2324.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
InParanoidi A9WEJ7.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CAUR324602:GIXU-2077-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29366 / DSM 635 / J-10-fl.

Entry informationi

Entry nameiPNP_CHLAA
AccessioniPrimary (citable) accession number: A9WEJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3