Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi493MagnesiumUniRule annotation1
Metal bindingi499MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciCAUR324602:G1GAO-2078-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Caur_2047
OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Taxonomic identifieri324602 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
Proteomesi
  • UP000002008 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003295881 – 755Polyribonucleotide nucleotidyltransferaseAdd BLAST755

Proteomic databases

PRIDEiA9WEJ7

Interactioni

Protein-protein interaction databases

STRINGi324602.Caur_2047

Structurei

3D structure databases

ProteinModelPortaliA9WEJ7
SMRiA9WEJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini560 – 619KHUniRule annotationAdd BLAST60
Domaini629 – 698S1 motifUniRule annotationAdd BLAST70

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218327
InParanoidiA9WEJ7
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

A9WEJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTERNIYSVS AEIAGRTLTL EAGRFAEQAD GAVVARYGDT MLLATVVCAK
60 70 80 90 100
EAREGTDFFP LTVDYEEKMY AVGKIPGNFF KREGRPTTTA ILISRLTDRP
110 120 130 140 150
LRPLFPKGFY NEVQVIITTF SIDMENDPGP LAIIAASAAL CISDIPFAGP
160 170 180 190 200
VGAVQMGHLN GQLVVNPKMN EIADSRLDLV VAGTKDAVLM VEAGAYELTE
210 220 230 240 250
DEMLQAVIDG HAVCKQICDL QEQLVQLCGK PKRPFTPPVV DTSLEEAISA
260 270 280 290 300
WMGDRLRKAV RSPIKQEREA QTEALKAEVI AHFTADEPEE EIANRTKEVT
310 320 330 340 350
KAFEKLLKDE VRNAILDEGI RVDGRALDEI RPISIEVGVI PRVHGSAVFT
360 370 380 390 400
RGQTQVLTIT TLGSPGDEQK VDDLGIETSK RYIHHYNFPP FSTGEVRRIG
410 420 430 440 450
TPRRRDIGHG ALAERSLYAV LPDEKDFPYT IRLVSEVLSS NGSSSMASVC
460 470 480 490 500
GSSLSLMDAG VPIKAPVAGV AMGLITGEDG RWRVLTDIQG LEDALGDMDF
510 520 530 540 550
KVAGTAKGVT GLQMDIKTTG ITYEIMREAF AQARAGRLFI LDKMNEVISA
560 570 580 590 600
PRPELSIYAP RIMTIQIPVD KIGALIGPGG KTIRNICETT GAQIDIEDDG
610 620 630 640 650
RVFITTPDGA AARQAISMIE GLTREAKVGD IFLGKVVSIK PFGAFVNILP
660 670 680 690 700
GKDGMVHVSE LDEKRVENVE DVVSLGDEIN VMVIDIDRTT GKISLSRRAV
710 720 730 740 750
LTGETPEERK AAGAAPRPRP REEQRGGRDE PRSLRDELRG PRREGDRPRP

RRRDD
Length:755
Mass (Da):82,432
Last modified:February 5, 2008 - v1
Checksum:iD293AA822551BDCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA Translation: ABY35259.1
RefSeqiWP_012257913.1, NC_010175.1
YP_001635648.1, NC_010175.1

Genome annotation databases

EnsemblBacteriaiABY35259; ABY35259; Caur_2047
GeneIDi5826502
KEGGicau:Caur_2047
PATRICifig|324602.8.peg.2324

Similar proteinsi

Entry informationi

Entry nameiPNP_CHLAA
AccessioniPrimary (citable) accession number: A9WEJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health