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Protein

Aspartate carbamoyltransferase

Gene

pyrB

Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Carbamoyl-phosphate synthase large chain (carB), Carbamoyl-phosphate synthase small chain (carA)
  2. Aspartate carbamoyltransferase (pyrB)
  3. Dihydroorotase (pyrC), Dihydroorotase (pyrC)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCAUR324602:G1GAO-1918-MONOMER.
UniPathwayiUPA00070; UER00116.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferaseUniRule annotation (EC:2.1.3.2UniRule annotation)
Alternative name(s):
Aspartate transcarbamylaseUniRule annotation
Short name:
ATCaseUniRule annotation
Gene namesi
Name:pyrBUniRule annotation
Ordered Locus Names:Caur_1891
OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Taxonomic identifieri324602 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
Proteomesi
  • UP000002008 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003291041 – 308Aspartate carbamoyltransferaseAdd BLAST308

Interactioni

Protein-protein interaction databases

STRINGi324602.Caur_1891.

Structurei

3D structure databases

ProteinModelPortaliA9WDU7.
SMRiA9WDU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXT. Bacteria.
COG0540. LUCA.
HOGENOMiHOG000022685.
InParanoidiA9WDU7.
KOiK00609.
OMAiWCDVANM.
OrthoDBiPOG091H00PQ.

Family and domain databases

Gene3Di3.40.50.1370. 3 hits.
HAMAPiMF_00001. Asp_carb_tr. 1 hit.
InterProiView protein in InterPro
IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR036901. Asp/Orn_carbamoylTrfase_sf.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
PANTHERiPTHR11405:SF16. PTHR11405:SF16. 1 hit.
PfamiView protein in Pfam
PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
PROSITEiView protein in PROSITE
PS00097. CARBAMOYLTRANSFERASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A9WDU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELRRHAID LDNFSATEIE EILETAESMR EVLSREIKQV PALRGKTVVN
60 70 80 90 100
MFFEESTRTR ISFELAARAL SANVVAFTAR GSSVEKGESL VDTVRTLQAL
110 120 130 140 150
GADIIVMRHS QSGAPYLVAR HFRGSLINAG DGRHAHPTQA LLDLYTMQSR
160 170 180 190 200
LGQIRDLHVV IVGDILHSRV VRSNLWGLTR LGARVTLCGP PTLIGPAAFW
210 220 230 240 250
TATWPQVRIA YELDPLLPEA DVVMALRLQK ERMQSGLLPA LREYTRIYGL
260 270 280 290 300
TSERLARLPS HAIVMHPGPM NEGIEIFPEV ATASPAVIEE QVTNGVAVRM

ALLYRMAG
Length:308
Mass (Da):34,064
Last modified:February 5, 2008 - v1
Checksum:i264B726D716B83D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA. Translation: ABY35106.1.
RefSeqiWP_012257760.1. NC_010175.1.
YP_001635495.1. NC_010175.1.

Genome annotation databases

EnsemblBacteriaiABY35106; ABY35106; Caur_1891.
GeneIDi5826342.
KEGGicau:Caur_1891.
PATRICifig|324602.8.peg.2160.

Similar proteinsi

Entry informationi

Entry nameiPYRB_CHLAA
AccessioniPrimary (citable) accession number: A9WDU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: February 5, 2008
Last modified: February 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome