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A9WBV3

- A9WBV3_CHLAA

UniProt

A9WBV3 - A9WBV3_CHLAA

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Protein
Submitted name: 2-oxoglutarate dehydrogenase, E1 subunit
Gene
Caur_3727
Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.SAAS annotations

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.SAAS annotations

Cofactori

Thiamine pyrophosphate By similarity.SAAS annotations

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotationsImported

Keywords - Biological processi

GlycolysisSAAS annotations

Keywords - Ligandi

Thiamine pyrophosphateSAAS annotations

Enzyme and pathway databases

BioCyciCAUR324602:GIXU-3781-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
2-oxoglutarate dehydrogenase, E1 subunitImported (EC:1.2.4.2Imported)
Gene namesi
Ordered Locus Names:Caur_3727Imported
OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)Imported
Taxonomic identifieri324602 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
ProteomesiUP000002008: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.SAAS annotations

Protein-protein interaction databases

STRINGi324602.Caur_3727.

Structurei

3D structure databases

ProteinModelPortaliA9WBV3.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiGFTTAPH.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

A9WBV3-1 [UniParc]FASTAAdd to Basket

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MNEWNGFYGP NAGYLIELYE RYCADPNSVD EATRAFFAQW APPSDSAAPA    50
GEAGQPPLDV TRIVGAARLI RYIRELGHLA ARIDPLGSDP PGDPGLELAT 100
HGVTQADLAA LPAHIVRGPI ATQVRNAAEG VERLRQAYSG SIGYETDQIQ 150
DYLERAWIRE AAEDRRFFGG LDADRQRELL DRLTEVECFE RFLHKTFPGQ 200
KRFSIEGCDM LIPMIDAIIR NAAVNGTKEV VIGMAHRGRL NVLAHILGKP 250
YSMILTEFHS PDYTKDTYEG WTGDVKYHLG ARKAYRESGI AEMPITLAPN 300
PSHLEFINPV VEGRARAAQE HRNRPGFPEE DEKESLAILI HGDAAFPGQG 350
IVAETLNLSR LKGYHTGGTI HIIINNQIGF TTDSNDSRST LYASDLARGL 400
EIPVVHVNAD DVEACIAAAR MASAYREKFQ KDFLIDLVGY RRWGHNEGDE 450
PEFTQPKMYE RIRNHPTVRE IWARELERRG IITREEAQAR VDAVMNRLQQ 500
AFEKVRERQR LAASLPPAPP PPVQPLRRPP IFARPVSAKT LIELNEALLD 550
RPEGFTVHPK LERTLQRRRQ AIFEESGIDW GHAEALAFAS ILADGTPIRL 600
TGQDSERGTF SHRHAVLHDV VTGERFIPLH HIPQARASFA VYNSPLSEAS 650
VLGFEYGYSC HAPDTLVLWE AQFGDFANGA QVIIDQFIVS GHAKWGQNPS 700
LVMLLPHGYE GQGPEHSSAR LERFLQLAAN DNIRVANCTT AAQYFHLLRY 750
QAASLYADPK PLIILTPKSL LRHPRSSSSL RDLTDHRFQP VLGLGAEAPA 800
PEGVTRLILC SGKVAIDLLS SAEWEKTAGR VDVLRLELLY PFPAEELRMA 850
MQRYPNLQEV VWLQEEPQNM GAWSFVWPRL QQLLPEGVTL RYVGRAESAS 900
PAEGLHSIHV REQARILREA VADLPESPVP ALQGRETMTR 940
Length:940
Mass (Da):105,012
Last modified:February 5, 2008 - v1
Checksum:i55D16A2D5777182A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000909 Genomic DNA. Translation: ABY36905.1.
RefSeqiYP_001637294.1. NC_010175.1.

Genome annotation databases

EnsemblBacteriaiABY36905; ABY36905; Caur_3727.
GeneIDi5825535.
KEGGicau:Caur_3727.
PATRICi21418902. VBIChlAur28763_4184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000909 Genomic DNA. Translation: ABY36905.1 .
RefSeqi YP_001637294.1. NC_010175.1.

3D structure databases

ProteinModelPortali A9WBV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 324602.Caur_3727.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY36905 ; ABY36905 ; Caur_3727 .
GeneIDi 5825535.
KEGGi cau:Caur_3727.
PATRICi 21418902. VBIChlAur28763_4184.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi GFTTAPH.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci CAUR324602:GIXU-3781-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29366 / DSM 635 / J-10-fl.

Entry informationi

Entry nameiA9WBV3_CHLAA
AccessioniPrimary (citable) accession number: A9WBV3
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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