A9WBV3 (A9WBV3_CHLAA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
2-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169
EC=1.2.4.2 HAMAP-Rule MF_01169

Alternative name(s):
Alpha-ketoglutarate dehydrogenase HAMAP-Rule MF_01169

Gene names

Name:	sucA HAMAP-Rule MF_01169
Synonyms:	odhA HAMAP-Rule MF_01169
Ordered Locus Names:	Caur_3727

Organism

Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) [Reference proteome] [HAMAP] EMBL ABY36905.1

Taxonomic identifier

324602 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chloroflexi › Chloroflexi › Chloroflexales › Chloroflexaceae › Chloroflexus › Chloroflexus aurantiacus

Protein attributes

Sequence length	940 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169 SAAS SAAS023784
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169 SAAS SAAS023784
Cofactor	Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169 SAAS SAAS023784
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_01169 SAAS SAAS023784
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family. HAMAP-Rule MF_01169

Ontologies

Keywords
Biological process	Glycolysis HAMAP-Rule MF_01169 SAAS SAAS023784
Ligand	Thiamine pyrophosphate HAMAP-Rule MF_01169 SAAS SAAS023784
Molecular function	Oxidoreductase HAMAP-Rule MF_01169 SAAS SAAS023784 EMBL ABY36905.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: HAMAP thiamine pyrophosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A9WBV3 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 55D16A2D5777182A	FASTA	940	105,012
	10 20 30 40 50 60 MNEWNGFYGP NAGYLIELYE RYCADPNSVD EATRAFFAQW APPSDSAAPA GEAGQPPLDV 70 80 90 100 110 120 TRIVGAARLI RYIRELGHLA ARIDPLGSDP PGDPGLELAT HGVTQADLAA LPAHIVRGPI 130 140 150 160 170 180 ATQVRNAAEG VERLRQAYSG SIGYETDQIQ DYLERAWIRE AAEDRRFFGG LDADRQRELL 190 200 210 220 230 240 DRLTEVECFE RFLHKTFPGQ KRFSIEGCDM LIPMIDAIIR NAAVNGTKEV VIGMAHRGRL 250 260 270 280 290 300 NVLAHILGKP YSMILTEFHS PDYTKDTYEG WTGDVKYHLG ARKAYRESGI AEMPITLAPN 310 320 330 340 350 360 PSHLEFINPV VEGRARAAQE HRNRPGFPEE DEKESLAILI HGDAAFPGQG IVAETLNLSR 370 380 390 400 410 420 LKGYHTGGTI HIIINNQIGF TTDSNDSRST LYASDLARGL EIPVVHVNAD DVEACIAAAR 430 440 450 460 470 480 MASAYREKFQ KDFLIDLVGY RRWGHNEGDE PEFTQPKMYE RIRNHPTVRE IWARELERRG 490 500 510 520 530 540 IITREEAQAR VDAVMNRLQQ AFEKVRERQR LAASLPPAPP PPVQPLRRPP IFARPVSAKT 550 560 570 580 590 600 LIELNEALLD RPEGFTVHPK LERTLQRRRQ AIFEESGIDW GHAEALAFAS ILADGTPIRL 610 620 630 640 650 660 TGQDSERGTF SHRHAVLHDV VTGERFIPLH HIPQARASFA VYNSPLSEAS VLGFEYGYSC 670 680 690 700 710 720 HAPDTLVLWE AQFGDFANGA QVIIDQFIVS GHAKWGQNPS LVMLLPHGYE GQGPEHSSAR 730 740 750 760 770 780 LERFLQLAAN DNIRVANCTT AAQYFHLLRY QAASLYADPK PLIILTPKSL LRHPRSSSSL 790 800 810 820 830 840 RDLTDHRFQP VLGLGAEAPA PEGVTRLILC SGKVAIDLLS SAEWEKTAGR VDVLRLELLY 850 860 870 880 890 900 PFPAEELRMA MQRYPNLQEV VWLQEEPQNM GAWSFVWPRL QQLLPEGVTL RYVGRAESAS 910 920 930 940 PAEGLHSIHV REQARILREA VADLPESPVP ALQGRETMTR

References

[1]

"Complete sequence of Chloroflexus aurantiacus J-10-fl." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Pierson B.K., Blankenship R.E., Richardson P. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29366 / DSM 635 / J-10-fl.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000909 Genomic DNA. Translation: ABY36905.1.
RefSeq	YP_001637294.1. NC_010175.1.
3D structure databases
ProteinModelPortal	A9WBV3.
ModBase	Search...
Protein-protein interaction databases
STRING	324602.Caur_3727.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABY36905; ABY36905; Caur_3727.
GeneID	5825535.
KEGG	cau:Caur_3727.
PATRIC	21418902. VBIChlAur28763_4184.
Phylogenomic databases
eggNOG	COG0567.
HOGENOM	HOG000259588.
KO	K00164.
OMA	IIKRGGA.
ProtClustDB	PRK09404.
Enzyme and pathway databases
BioCyc	CAUR324602:GIXU-3781-MONOMER.
Family and domain databases
HAMAP	MF_01169. SucA_OdhA.
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR023784. 2oxoglutarate_DH_E1_bac. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
PANTHER	PTHR23152. PTHR23152. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A9WBV3_CHLAA

Accession

Primary (citable) accession number: A9WBV3

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)