Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A9WBV3

- A9WBV3_CHLAA

UniProt

A9WBV3 - A9WBV3_CHLAA

Protein
Submitted name:

2-oxoglutarate dehydrogenase, E1 subunit

Gene

Caur_3727

Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).SAAS annotation

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.SAAS annotation

    Cofactori

    Thiamine pyrophosphate.SAAS annotation

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseSAAS annotationImported

    Keywords - Biological processi

    GlycolysisSAAS annotation

    Keywords - Ligandi

    Thiamine pyrophosphateSAAS annotation

    Enzyme and pathway databases

    BioCyciCAUR324602:GIXU-3781-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    2-oxoglutarate dehydrogenase, E1 subunitImported (EC:1.2.4.2Imported)
    Gene namesi
    Ordered Locus Names:Caur_3727Imported
    OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)Imported
    Taxonomic identifieri324602 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
    ProteomesiUP000002008: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.SAAS annotation

    Protein-protein interaction databases

    STRINGi324602.Caur_3727.

    Structurei

    3D structure databases

    ProteinModelPortaliA9WBV3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0567.
    HOGENOMiHOG000259588.
    KOiK00164.
    OMAiGFTTAPH.
    OrthoDBiEOG6V1M1F.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    HAMAPiMF_01169. SucA_OdhA.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9WBV3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNEWNGFYGP NAGYLIELYE RYCADPNSVD EATRAFFAQW APPSDSAAPA    50
    GEAGQPPLDV TRIVGAARLI RYIRELGHLA ARIDPLGSDP PGDPGLELAT 100
    HGVTQADLAA LPAHIVRGPI ATQVRNAAEG VERLRQAYSG SIGYETDQIQ 150
    DYLERAWIRE AAEDRRFFGG LDADRQRELL DRLTEVECFE RFLHKTFPGQ 200
    KRFSIEGCDM LIPMIDAIIR NAAVNGTKEV VIGMAHRGRL NVLAHILGKP 250
    YSMILTEFHS PDYTKDTYEG WTGDVKYHLG ARKAYRESGI AEMPITLAPN 300
    PSHLEFINPV VEGRARAAQE HRNRPGFPEE DEKESLAILI HGDAAFPGQG 350
    IVAETLNLSR LKGYHTGGTI HIIINNQIGF TTDSNDSRST LYASDLARGL 400
    EIPVVHVNAD DVEACIAAAR MASAYREKFQ KDFLIDLVGY RRWGHNEGDE 450
    PEFTQPKMYE RIRNHPTVRE IWARELERRG IITREEAQAR VDAVMNRLQQ 500
    AFEKVRERQR LAASLPPAPP PPVQPLRRPP IFARPVSAKT LIELNEALLD 550
    RPEGFTVHPK LERTLQRRRQ AIFEESGIDW GHAEALAFAS ILADGTPIRL 600
    TGQDSERGTF SHRHAVLHDV VTGERFIPLH HIPQARASFA VYNSPLSEAS 650
    VLGFEYGYSC HAPDTLVLWE AQFGDFANGA QVIIDQFIVS GHAKWGQNPS 700
    LVMLLPHGYE GQGPEHSSAR LERFLQLAAN DNIRVANCTT AAQYFHLLRY 750
    QAASLYADPK PLIILTPKSL LRHPRSSSSL RDLTDHRFQP VLGLGAEAPA 800
    PEGVTRLILC SGKVAIDLLS SAEWEKTAGR VDVLRLELLY PFPAEELRMA 850
    MQRYPNLQEV VWLQEEPQNM GAWSFVWPRL QQLLPEGVTL RYVGRAESAS 900
    PAEGLHSIHV REQARILREA VADLPESPVP ALQGRETMTR 940
    Length:940
    Mass (Da):105,012
    Last modified:February 5, 2008 - v1
    Checksum:i55D16A2D5777182A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000909 Genomic DNA. Translation: ABY36905.1.
    RefSeqiYP_001637294.1. NC_010175.1.

    Genome annotation databases

    EnsemblBacteriaiABY36905; ABY36905; Caur_3727.
    GeneIDi5825535.
    KEGGicau:Caur_3727.
    PATRICi21418902. VBIChlAur28763_4184.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000909 Genomic DNA. Translation: ABY36905.1 .
    RefSeqi YP_001637294.1. NC_010175.1.

    3D structure databases

    ProteinModelPortali A9WBV3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 324602.Caur_3727.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY36905 ; ABY36905 ; Caur_3727 .
    GeneIDi 5825535.
    KEGGi cau:Caur_3727.
    PATRICi 21418902. VBIChlAur28763_4184.

    Phylogenomic databases

    eggNOGi COG0567.
    HOGENOMi HOG000259588.
    KOi K00164.
    OMAi GFTTAPH.
    OrthoDBi EOG6V1M1F.

    Enzyme and pathway databases

    BioCyci CAUR324602:GIXU-3781-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    HAMAPi MF_01169. SucA_OdhA.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR023784. 2oxoglutarate_DH_E1_bac.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29366 / DSM 635 / J-10-flImported.

    Entry informationi

    Entry nameiA9WBV3_CHLAA
    AccessioniPrimary (citable) accession number: A9WBV3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3