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A9WBV3

- A9WBV3_CHLAA

UniProt

A9WBV3 - A9WBV3_CHLAA

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Protein
Submitted name:

2-oxoglutarate dehydrogenase, E1 subunit

Gene

Caur_3727

Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).SAAS annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.SAAS annotation

Cofactori

Note: Thiamine pyrophosphate.SAAS annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotationImported

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

Thiamine pyrophosphateSAAS annotation

Enzyme and pathway databases

BioCyciCAUR324602:GIXU-3781-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
2-oxoglutarate dehydrogenase, E1 subunitImported (EC:1.2.4.2Imported)
Gene namesi
Ordered Locus Names:Caur_3727Imported
OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)Imported
Taxonomic identifieri324602 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
ProteomesiUP000002008: Chromosome

Interactioni

Subunit structurei

Homodimer.SAAS annotation

Protein-protein interaction databases

STRINGi324602.Caur_3727.

Structurei

3D structure databases

ProteinModelPortaliA9WBV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
InParanoidiA9WBV3.
KOiK00164.
OMAiGFTTAPH.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

A9WBV3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEWNGFYGP NAGYLIELYE RYCADPNSVD EATRAFFAQW APPSDSAAPA
60 70 80 90 100
GEAGQPPLDV TRIVGAARLI RYIRELGHLA ARIDPLGSDP PGDPGLELAT
110 120 130 140 150
HGVTQADLAA LPAHIVRGPI ATQVRNAAEG VERLRQAYSG SIGYETDQIQ
160 170 180 190 200
DYLERAWIRE AAEDRRFFGG LDADRQRELL DRLTEVECFE RFLHKTFPGQ
210 220 230 240 250
KRFSIEGCDM LIPMIDAIIR NAAVNGTKEV VIGMAHRGRL NVLAHILGKP
260 270 280 290 300
YSMILTEFHS PDYTKDTYEG WTGDVKYHLG ARKAYRESGI AEMPITLAPN
310 320 330 340 350
PSHLEFINPV VEGRARAAQE HRNRPGFPEE DEKESLAILI HGDAAFPGQG
360 370 380 390 400
IVAETLNLSR LKGYHTGGTI HIIINNQIGF TTDSNDSRST LYASDLARGL
410 420 430 440 450
EIPVVHVNAD DVEACIAAAR MASAYREKFQ KDFLIDLVGY RRWGHNEGDE
460 470 480 490 500
PEFTQPKMYE RIRNHPTVRE IWARELERRG IITREEAQAR VDAVMNRLQQ
510 520 530 540 550
AFEKVRERQR LAASLPPAPP PPVQPLRRPP IFARPVSAKT LIELNEALLD
560 570 580 590 600
RPEGFTVHPK LERTLQRRRQ AIFEESGIDW GHAEALAFAS ILADGTPIRL
610 620 630 640 650
TGQDSERGTF SHRHAVLHDV VTGERFIPLH HIPQARASFA VYNSPLSEAS
660 670 680 690 700
VLGFEYGYSC HAPDTLVLWE AQFGDFANGA QVIIDQFIVS GHAKWGQNPS
710 720 730 740 750
LVMLLPHGYE GQGPEHSSAR LERFLQLAAN DNIRVANCTT AAQYFHLLRY
760 770 780 790 800
QAASLYADPK PLIILTPKSL LRHPRSSSSL RDLTDHRFQP VLGLGAEAPA
810 820 830 840 850
PEGVTRLILC SGKVAIDLLS SAEWEKTAGR VDVLRLELLY PFPAEELRMA
860 870 880 890 900
MQRYPNLQEV VWLQEEPQNM GAWSFVWPRL QQLLPEGVTL RYVGRAESAS
910 920 930 940
PAEGLHSIHV REQARILREA VADLPESPVP ALQGRETMTR
Length:940
Mass (Da):105,012
Last modified:February 5, 2008 - v1
Checksum:i55D16A2D5777182A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA. Translation: ABY36905.1.
RefSeqiYP_001637294.1. NC_010175.1.

Genome annotation databases

EnsemblBacteriaiABY36905; ABY36905; Caur_3727.
GeneIDi5825535.
KEGGicau:Caur_3727.
PATRICi21418902. VBIChlAur28763_4184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA. Translation: ABY36905.1 .
RefSeqi YP_001637294.1. NC_010175.1.

3D structure databases

ProteinModelPortali A9WBV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 324602.Caur_3727.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY36905 ; ABY36905 ; Caur_3727 .
GeneIDi 5825535.
KEGGi cau:Caur_3727.
PATRICi 21418902. VBIChlAur28763_4184.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
InParanoidi A9WBV3.
KOi K00164.
OMAi GFTTAPH.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci CAUR324602:GIXU-3781-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29366 / DSM 635 / J-10-flImported.

Entry informationi

Entry nameiA9WBV3_CHLAA
AccessioniPrimary (citable) accession number: A9WBV3
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3