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A9WBV3 (A9WBV3_CHLAA) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
EC=1.2.4.2 EMBL ABY36905.1
Gene names
Ordered Locus Names:Caur_3727 EMBL ABY36905.1
OrganismChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) [Reference proteome] [HAMAP] EMBL ABY36905.1
Taxonomic identifier324602 [NCBI]
Taxonomic lineageBacteriaChloroflexiChloroflexalesChloroflexaceaeChloroflexus

Protein attributes

Sequence length940 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. SAAS SAAS023784

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. SAAS SAAS023784

Cofactor

Thiamine pyrophosphate By similarity. SAAS SAAS023784

Subunit structure

Homodimer By similarity. SAAS SAAS023784

Sequences

Sequence LengthMass (Da)Tools
A9WBV3 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 55D16A2D5777182A

FASTA940105,012
        10         20         30         40         50         60 
MNEWNGFYGP NAGYLIELYE RYCADPNSVD EATRAFFAQW APPSDSAAPA GEAGQPPLDV 

        70         80         90        100        110        120 
TRIVGAARLI RYIRELGHLA ARIDPLGSDP PGDPGLELAT HGVTQADLAA LPAHIVRGPI 

       130        140        150        160        170        180 
ATQVRNAAEG VERLRQAYSG SIGYETDQIQ DYLERAWIRE AAEDRRFFGG LDADRQRELL 

       190        200        210        220        230        240 
DRLTEVECFE RFLHKTFPGQ KRFSIEGCDM LIPMIDAIIR NAAVNGTKEV VIGMAHRGRL 

       250        260        270        280        290        300 
NVLAHILGKP YSMILTEFHS PDYTKDTYEG WTGDVKYHLG ARKAYRESGI AEMPITLAPN 

       310        320        330        340        350        360 
PSHLEFINPV VEGRARAAQE HRNRPGFPEE DEKESLAILI HGDAAFPGQG IVAETLNLSR 

       370        380        390        400        410        420 
LKGYHTGGTI HIIINNQIGF TTDSNDSRST LYASDLARGL EIPVVHVNAD DVEACIAAAR 

       430        440        450        460        470        480 
MASAYREKFQ KDFLIDLVGY RRWGHNEGDE PEFTQPKMYE RIRNHPTVRE IWARELERRG 

       490        500        510        520        530        540 
IITREEAQAR VDAVMNRLQQ AFEKVRERQR LAASLPPAPP PPVQPLRRPP IFARPVSAKT 

       550        560        570        580        590        600 
LIELNEALLD RPEGFTVHPK LERTLQRRRQ AIFEESGIDW GHAEALAFAS ILADGTPIRL 

       610        620        630        640        650        660 
TGQDSERGTF SHRHAVLHDV VTGERFIPLH HIPQARASFA VYNSPLSEAS VLGFEYGYSC 

       670        680        690        700        710        720 
HAPDTLVLWE AQFGDFANGA QVIIDQFIVS GHAKWGQNPS LVMLLPHGYE GQGPEHSSAR 

       730        740        750        760        770        780 
LERFLQLAAN DNIRVANCTT AAQYFHLLRY QAASLYADPK PLIILTPKSL LRHPRSSSSL 

       790        800        810        820        830        840 
RDLTDHRFQP VLGLGAEAPA PEGVTRLILC SGKVAIDLLS SAEWEKTAGR VDVLRLELLY 

       850        860        870        880        890        900 
PFPAEELRMA MQRYPNLQEV VWLQEEPQNM GAWSFVWPRL QQLLPEGVTL RYVGRAESAS 

       910        920        930        940 
PAEGLHSIHV REQARILREA VADLPESPVP ALQGRETMTR 

« Hide

References

[1]"Complete genome sequence of the filamentous anoxygenic phototrophic bacterium Chloroflexus aurantiacus."
Tang K.H., Barry K., Chertkov O., Dalin E., Han C.S., Hauser L.J., Honchak B.M., Karbach L.E., Land M.L., Lapidus A., Larimer F.W., Mikhailova N., Pitluck S., Pierson B.K., Blankenship R.E.
BMC Genomics 12:334-334(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29366 / DSM 635 / J-10-fl.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000909 Genomic DNA. Translation: ABY36905.1.
RefSeqYP_001637294.1. NC_010175.1.

3D structure databases

ProteinModelPortalA9WBV3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING324602.Caur_3727.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABY36905; ABY36905; Caur_3727.
GeneID5825535.
KEGGcau:Caur_3727.
PATRIC21418902. VBIChlAur28763_4184.

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259588.
KOK00164.
OMARSEAGYP.
OrthoDBEOG6V1M1F.
ProtClustDBPRK09404.

Enzyme and pathway databases

BioCycCAUR324602:GIXU-3781-MONOMER.

Family and domain databases

HAMAPMF_01169. SucA_OdhA.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA9WBV3_CHLAA
AccessionPrimary (citable) accession number: A9WBV3
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: February 19, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)