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Protein

L-lactate dehydrogenase

Gene

ldh

Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92SubstrateUniRule annotation1
Binding sitei124NAD or substrateUniRule annotation1
Binding sitei124SubstrateUniRule annotation1
Binding sitei155SubstrateUniRule annotation1
Active sitei179Proton acceptorUniRule annotation1
Binding sitei234SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 44NADUniRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDHUniRule annotation
Gene namesi
Name:ldhUniRule annotation
Ordered Locus Names:Caur_1675Imported
OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)Imported
Taxonomic identifieri324602 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
Proteomesi
  • UP000002008 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei225PhosphotyrosineUniRule annotation1

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi324602.Caur_1675.

Structurei

3D structure databases

ProteinModelPortaliA9WBT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 146Ldh_1_NInterPro annotationAdd BLAST138
Domaini149 – 313Ldh_1_CInterPro annotationAdd BLAST165

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213793.
InParanoidiA9WBT6.
KOiK00016.
OMAiRQPGQTR.
OrthoDBiPOG091H02EQ.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

A9WBT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRKRTGKV GVVGTGMVGT SFAYALMQRS LASELVLIDI DHARAEGEAM
60 70 80 90 100
DLNHGLPFVR PMRIYAGTYD DLAGADLIVI AAGANQRPGE TRLDLLNRNV
110 120 130 140 150
AIFREIIPPI LAANDDGIIV VATNPVDILT TIGAQIAGPA ANRVIGSGTI
160 170 180 190 200
LDTARFRYLL GQHYGVDPRS VHAYIVGEHG DSELALWSLA NIAGVRLVDF
210 220 230 240 250
VGANGQGYNQ AALDAILEQT RNAAYEIIKR KRATYYAIGL GLLSIAEAVL
260 270 280 290 300
RDQHTVMTIS SLMNGQYGVS GIAISLPTIV GRDGAEEVLN LPLSEQEIAL
310
FQRSAGILKE HLSHVQ
Length:316
Mass (Da):33,833
Last modified:February 5, 2008 - v1
Checksum:iCF9527E30CBC01B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA. Translation: ABY34893.1.
RefSeqiWP_012257547.1. NC_010175.1.
YP_001635282.1. NC_010175.1.

Genome annotation databases

EnsemblBacteriaiABY34893; ABY34893; Caur_1675.
GeneIDi5826124.
KEGGicau:Caur_1675.
PATRICifig|324602.8.peg.1914.

Similar proteinsi

Entry informationi

Entry nameiA9WBT6_CHLAA
AccessioniPrimary (citable) accession number: A9WBT6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 22, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported