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A9WBA4 (AROA_CHLAA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS
Gene names
Name:aroA
Ordered Locus Names:Caur_0057
OrganismChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Taxonomic identifier324602 [NCBI]
Taxonomic lineageBacteria › Chloroflexi › Chloroflexales › Chloroflexaceae › Chloroflexus

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210

Subunit structure

Monomer By similarity. HAMAP MF_00210

Subcellular location

Cytoplasm By similarity HAMAP MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4354353-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210
PRO_1000077984

Sequences

Sequence LengthMass (Da)Tools
A9WBA4 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: F7FA659FAFBF9D8B

FASTA43545,498
        10         20         30         40         50         60 
MKGITLTAPK RLRGVIEVPG DKSISHRSVL FNAIATGSAH ITHFLPGADC LSTVACIRAL 

        70         80         90        100        110        120 
GVTVEQPAER ELIVHGVGLG GLREPADVLD CGNSGTTLRL LAGLLAGHPF FSVLTGDASL 

       130        140        150        160        170        180 
RSRPQRRIVV PLRAMGAQID GRDDGDRAPL AIRGNRLRGG HYELSIASAQ VKSALLLAAL 

       190        200        210        220        230        240 
NAEQPLTLTG RIDSRDHTER MLAAMGLEIT VTADQITIQP PSEATAPTAL SLRVPGDPSS 

       250        260        270        280        290        300 
AAFWWVAAAI HPDAELVTPG VCLNPTRIGA IEVLQAMGAD LTVMNERLEG SEPVGDVVVR 

       310        320        330        340        350        360 
SSSLRGTTIA GTLIPRLIDE IPVLAVAAAC ASGETVIRDA QELRAKETDR IATVAAGLSA 

       370        380        390        400        410        420 
MGAVVEPTAD GMVIVGQPGQ LQGTTLNSFH DHRLAMAWAI AAMVARGETT ILEPAAAAVS 

       430 
YPEFWQTLAM VQEAA

« Hide

References

[1]"Complete sequence of Chloroflexus aurantiacus J-10-fl."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Mikhailova N., Pierson B.K., Blankenship R.E., Richardson P.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29366 / DSM 635 / J-10-fl.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000909 Genomic DNA. Translation: ABY33311.1.
RefSeqYP_001633700.1. NC_010175.1.

3D structure databases

ProteinModelPortalA9WBA4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9WBA4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5828194.
GenomeReviewsGene locus Caur_0057 in contig CP000909_GR.
KEGGcau:Caur_0057.
PATRIC21410551. VBIChlAur28763_0063.

Phylogenomic databases

HOGENOMHBG646626.
OMALECANIS.
PhylomeDBA9WBA4.
ProtClustDBPRK02427.

Family and domain databases

HAMAPMF_00210. EPSP_synth.
[Tree]
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KOK00800.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01356. AroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA_CHLAA
AccessionPrimary (citable) accession number: A9WBA4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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