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Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtnP

Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: L-methionine biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. S-methyl-5'-thioadenosine phosphorylase (mtnP)
This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route), the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12PhosphateUniRule annotation1
Sitei168Important for substrate specificityUniRule annotation1
Binding sitei186Substrate; via amide nitrogenUniRule annotation1
Binding sitei187PhosphateUniRule annotation1
Sitei223Important for substrate specificityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Enzyme and pathway databases

BioCyciCAUR324602:G1GAO-3673-MONOMER
UniPathwayiUPA00904; UER00873

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
Alternative name(s):
5'-methylthioadenosine phosphorylaseUniRule annotation
Short name:
MTA phosphorylaseUniRule annotation
Short name:
MTAPUniRule annotation
Gene namesi
Name:mtnPUniRule annotation
Ordered Locus Names:Caur_3616
OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Taxonomic identifieri324602 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
Proteomesi
  • UP000002008 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004150911 – 288S-methyl-5'-thioadenosine phosphorylaseAdd BLAST288

Proteomic databases

PRIDEiA9WAL0

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi324602.Caur_3616

Structurei

3D structure databases

ProteinModelPortaliA9WAL0
SMRiA9WAL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 55Phosphate bindingUniRule annotation2
Regioni87 – 88Phosphate bindingUniRule annotation2
Regioni210 – 212Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RHB Bacteria
COG0005 LUCA
HOGENOMiHOG000228986
InParanoidiA9WAL0
KOiK00772
OMAiNLYRSWG
OrthoDBiPOG091H0228

Family and domain databases

HAMAPiMF_01963 MTAP, 1 hit
InterProiView protein in InterPro
IPR010044 MTAP
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR018099 Purine_phosphorylase-2_CS
PANTHERiPTHR42679 PTHR42679, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01694 MTAP, 1 hit
PROSITEiView protein in PROSITE
PS01240 PNP_MTAP_2, 1 hit

Sequencei

Sequence statusi: Complete.

A9WAL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSATIGVIG GSGLYAMPDL KNPEEVRLTT PFGDPSDAFI IGELEGRRVA
60 70 80 90 100
FLPRHGRGHR LNPSEVPARA NIYAFKLLGV RALISVSAVG SLREDYAPGH
110 120 130 140 150
AVIPDQIFDR TKGIRPATFF EGGVVAHVAF DRPFCPYLSN ILLHAAQAAG
160 170 180 190 200
AVVHQGGTLV VMEGPQFSTK AESEENRRRG HSLIGMTALP EAKLAREAEI
210 220 230 240 250
AYATLAMVTD YDVWHPEHDA VTAEQVIKVL SANVNLSQQI VRHAVAQIDE
260 270 280
NFTSPAHDAL RYAIVTHPDH IPAAVKERLA PIAGRYWS
Length:288
Mass (Da):31,271
Last modified:February 5, 2008 - v1
Checksum:i114F997E0A557003
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA Translation: ABY36800.1
RefSeqiWP_012259453.1, NC_010175.1
YP_001637189.1, NC_010175.1

Genome annotation databases

EnsemblBacteriaiABY36800; ABY36800; Caur_3616
GeneIDi5825423
KEGGicau:Caur_3616
PATRICifig|324602.8.peg.4071

Similar proteinsi

Entry informationi

Entry nameiMTAP_CHLAA
AccessioniPrimary (citable) accession number: A9WAL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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