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Protein

Anthranilate synthase component 1

Gene

trpE

Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.UniRule annotation

Catalytic activityi

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciCAUR324602:G1GAO-1430-MONOMER
UniPathwayiUPA00035; UER00040

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate synthase component 1UniRule annotation (EC:4.1.3.27UniRule annotation)
Gene namesi
Name:trpEUniRule annotation
Ordered Locus Names:Caur_1408Imported
OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)Imported
Taxonomic identifieri324602 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
Proteomesi
  • UP000002008 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).UniRule annotation

Protein-protein interaction databases

STRINGi324602.Caur_1408

Structurei

3D structure databases

ProteinModelPortaliA9WA77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 166Anth_synt_I_NInterPro annotationAdd BLAST139
Domaini232 – 485Chorismate_bindInterPro annotationAdd BLAST254

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili176 – 196Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the anthranilate synthase component I family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105CRQ Bacteria
COG0147 LUCA
HOGENOMiHOG000025142
InParanoidiA9WA77
KOiK01657
OMAiIAGTFKR
OrthoDBiPOG091H01VQ

Family and domain databases

Gene3Di3.60.120.10, 1 hit
InterProiView protein in InterPro
IPR005801 ADC_synthase
IPR019999 Anth_synth_I-like
IPR006805 Anth_synth_I_N
IPR005256 Anth_synth_I_PabB
IPR015890 Chorismate_C
PfamiView protein in Pfam
PF04715 Anth_synt_I_N, 1 hit
PF00425 Chorismate_bind, 1 hit
PRINTSiPR00095 ANTSNTHASEI
SUPFAMiSSF56322 SSF56322, 1 hit
TIGRFAMsiTIGR00564 trpE_most, 1 hit

Sequencei

Sequence statusi: Complete.

A9WA77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYYPTLDQLQ ELRQQGNLCP IYREIMADLE TPVSAYLKIA QGGLGFLLES
60 70 80 90 100
VTGGQNIGRY SFIGSDPYMV LRMHDGVAQA THGGYKQTLT YTDPLIVLES
110 120 130 140 150
YLNAYRPIRL PNLPIFVGGA VGYLNYESAR YFERLPVPPV RPYDMPDSWW
160 170 180 190 200
MFVDTLLAFD HVRHKIIVIS HVHLDVEDLA AEYQRAVQRI ETLIARLQRP
210 220 230 240 250
LPPGIGLSLR NYEPHNTPAR VMTNPIVSNR TEAEFKAAVL RAKEYIMAGD
260 270 280 290 300
IFQVQISQRF SKATSADSFT IYRALRTINP SPYMFYIRTG EGDLVGASPE
310 320 330 340 350
MLVQVRDGKV TTRPIAGTRW RGRDAAEDEQ LAADLLADEK ERAEHLMLVD
360 370 380 390 400
LGRNDLGRIS QPGTVQVPVF MTIEKYSHVQ HIVSEVTGLL RADLKPIDAL
410 420 430 440 450
RACFPAGTVT GAPKIRSMEI IAELEGEQRG IYAGAVGHLG FNGDLDTCIA
460 470 480 490 500
LRTLIVKDGI AYAQAAAGVV ADSTPEYEFN ESCNKAAASL RAIDLAEELQ

AGG
Length:503
Mass (Da):55,761
Last modified:February 5, 2008 - v1
Checksum:i5A37CC61DFF895FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000909 Genomic DNA Translation: ABY34636.1
RefSeqiWP_012257292.1, NC_010175.1
YP_001635025.1, NC_010175.1

Genome annotation databases

EnsemblBacteriaiABY34636; ABY34636; Caur_1408
GeneIDi5828514
KEGGicau:Caur_1408
PATRICifig|324602.8.peg.1603

Similar proteinsi

Entry informationi

Entry nameiA9WA77_CHLAA
AccessioniPrimary (citable) accession number: A9WA77
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: February 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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