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A9W9U2

- ACDH_CHLAA

UniProt

A9W9U2 - ACDH_CHLAA

Protein

Acetaldehyde dehydrogenase

Gene

Caur_1350

Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei128 – 1281Acyl-thioester intermediateUniRule annotation
    Binding sitei278 – 2781NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 164NADUniRule annotation
    Nucleotide bindingi159 – 1679NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciCAUR324602:GIXU-1370-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]UniRule annotation
    Gene namesi
    Ordered Locus Names:Caur_1350
    OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
    Taxonomic identifieri324602 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
    ProteomesiUP000002008: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Acetaldehyde dehydrogenasePRO_0000387649Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi324602.Caur_1350.

    Structurei

    3D structure databases

    ProteinModelPortaliA9W9U2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiHQGNVNM.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9W9U2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQIDKVKVAI LGSGNIGTDL MYKLLKQPGR MELALVAGID PASEGLARAR    50
    QIGIPTATDG IESILADPDI RIVFDATSAK AHVRHARLLR DHGRIAIDLT 100
    PAARGPYVVP PVNLGEHLEA HNVNLITCGG QATIPLVYAV SRVTAVRYAE 150
    MVSTVASRSA GPGTRQNIDE FTFTTARGLE AIGGAREAKA IIILNPAHPP 200
    ILMRNTIYVV PEGDFDEETV RQSVAQMVAD VQQYVPGYRL KSLPVIEQRS 250
    TPWGERPVII MLLEVEGAGD FLPTYAGNLD IMTAAARRVG ELFAAHLLSK 300
    LEVTV 305
    Length:305
    Mass (Da):32,852
    Last modified:February 5, 2008 - v1
    Checksum:i84E757C1B25C747C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000909 Genomic DNA. Translation: ABY34578.1.
    RefSeqiYP_001634967.1. NC_010175.1.

    Genome annotation databases

    EnsemblBacteriaiABY34578; ABY34578; Caur_1350.
    GeneIDi5828455.
    KEGGicau:Caur_1350.
    PATRICi21413541. VBIChlAur28763_1538.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000909 Genomic DNA. Translation: ABY34578.1 .
    RefSeqi YP_001634967.1. NC_010175.1.

    3D structure databases

    ProteinModelPortali A9W9U2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 324602.Caur_1350.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY34578 ; ABY34578 ; Caur_1350 .
    GeneIDi 5828455.
    KEGGi cau:Caur_1350.
    PATRICi 21413541. VBIChlAur28763_1538.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi HQGNVNM.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci CAUR324602:GIXU-1370-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29366 / DSM 635 / J-10-fl.

    Entry informationi

    Entry nameiACDH_CHLAA
    AccessioniPrimary (citable) accession number: A9W9U2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3