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A9W9U2

- ACDH_CHLAA

UniProt

A9W9U2 - ACDH_CHLAA

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Protein

Acetaldehyde dehydrogenase

Gene

Caur_1350

Organism
Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei128 – 1281Acyl-thioester intermediateUniRule annotation
Binding sitei278 – 2781NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 164NADUniRule annotation
Nucleotide bindingi159 – 1679NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCAUR324602:GIXU-1370-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
Ordered Locus Names:Caur_1350
OrganismiChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
Taxonomic identifieri324602 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
ProteomesiUP000002008: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Acetaldehyde dehydrogenasePRO_0000387649Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi324602.Caur_1350.

Structurei

3D structure databases

ProteinModelPortaliA9W9U2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
InParanoidiA9W9U2.
KOiK04073.
OMAiHQGNVNM.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

A9W9U2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQIDKVKVAI LGSGNIGTDL MYKLLKQPGR MELALVAGID PASEGLARAR
60 70 80 90 100
QIGIPTATDG IESILADPDI RIVFDATSAK AHVRHARLLR DHGRIAIDLT
110 120 130 140 150
PAARGPYVVP PVNLGEHLEA HNVNLITCGG QATIPLVYAV SRVTAVRYAE
160 170 180 190 200
MVSTVASRSA GPGTRQNIDE FTFTTARGLE AIGGAREAKA IIILNPAHPP
210 220 230 240 250
ILMRNTIYVV PEGDFDEETV RQSVAQMVAD VQQYVPGYRL KSLPVIEQRS
260 270 280 290 300
TPWGERPVII MLLEVEGAGD FLPTYAGNLD IMTAAARRVG ELFAAHLLSK

LEVTV
Length:305
Mass (Da):32,852
Last modified:February 5, 2008 - v1
Checksum:i84E757C1B25C747C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000909 Genomic DNA. Translation: ABY34578.1.
RefSeqiYP_001634967.1. NC_010175.1.

Genome annotation databases

EnsemblBacteriaiABY34578; ABY34578; Caur_1350.
GeneIDi5828455.
KEGGicau:Caur_1350.
PATRICi21413541. VBIChlAur28763_1538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000909 Genomic DNA. Translation: ABY34578.1 .
RefSeqi YP_001634967.1. NC_010175.1.

3D structure databases

ProteinModelPortali A9W9U2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 324602.Caur_1350.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY34578 ; ABY34578 ; Caur_1350 .
GeneIDi 5828455.
KEGGi cau:Caur_1350.
PATRICi 21413541. VBIChlAur28763_1538.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
InParanoidi A9W9U2.
KOi K04073.
OMAi HQGNVNM.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci CAUR324602:GIXU-1370-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29366 / DSM 635 / J-10-fl.

Entry informationi

Entry nameiACDH_CHLAA
AccessioniPrimary (citable) accession number: A9W9U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3