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Protein

Argininosuccinate lyase

Gene

argH

Organism
Methylobacterium extorquens (strain PA1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciMEXT419610:G1GAN-3393-MONOMER.
UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Mext_3289
OrganismiMethylobacterium extorquens (strain PA1)
Taxonomic identifieri419610 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000008546 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000890911 – 463Argininosuccinate lyaseAdd BLAST463

Interactioni

Protein-protein interaction databases

STRINGi419610.Mext_3289.

Structurei

3D structure databases

ProteinModelPortaliA9W714.
SMRiA9W714.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7. Bacteria.
COG0165. LUCA.
HOGENOMiHOG000242744.
KOiK01755.
OMAiSIMPHKK.
OrthoDBiPOG091H026A.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 2 hits.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiView protein in InterPro
IPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
PANTHERiPTHR43814. PTHR43814. 1 hit.
PfamiView protein in Pfam
PF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiView protein in PROSITE
PS00163. FUMARATE_LYASES. 1 hit.

Sequencei

Sequence statusi: Complete.

A9W714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNRMWGGRF ASGPAEIMEE INASIGFDRR LASQDIRGSL AHVAMLGSQG
60 70 80 90 100
ILPAEDVAAI EAGLKSVEAE IARGEFVFRR ELEDIHMAVE SRLTEIVGPA
110 120 130 140 150
AGRLHTARSR NDQVATDMRL WVRDTLDALD AQVADLQRAL AETAVKHAGT
160 170 180 190 200
VMPGFTHLQS AQPVTFGHHC LAYVEMLARD RGRFRDARAR LNECPLGAAA
210 220 230 240 250
LAGTSFPIDR HATAAALGFD RPTANSLDSV ADRDFALESL SAASICAVHL
260 270 280 290 300
SRFAEELVVW TSAQFGFVRL SDGFTTGSSI MPQKRNPDAA ELVRAKAGRI
310 320 330 340 350
IGALTGLLIV MKGLPLAYSK DMQEDKEGTF DALQSLSLCL AAMAGMVRDL
360 370 380 390 400
EPVAETLKRA AGSGYATATD LADWLVRELN MPFRQAHHVT GRVVAAASER
410 420 430 440 450
GIGLEELSLQ GMQAIEPGIT DAVFAVLGVE NSVASRTSYG GTAPDNVRRQ
460
AAAWLEKLGP VEK
Length:463
Mass (Da):49,644
Last modified:February 5, 2008 - v1
Checksum:iD8927DDFB02D2398
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000908 Genomic DNA. Translation: ABY31676.1.
RefSeqiWP_012254558.1. NC_010172.1.

Genome annotation databases

EnsemblBacteriaiABY31676; ABY31676; Mext_3289.
KEGGimex:Mext_3289.

Similar proteinsi

Entry informationi

Entry nameiARLY_METEP
AccessioniPrimary (citable) accession number: A9W714
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 5, 2008
Last modified: February 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome