A9W706 (A9W706_METEP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA 2 HAMAP MF_01401
Short name=Protein-methionine-S-oxide reductase 2 HAMAP MF_01401
EC=1.8.4.11 HAMAP MF_01401

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 2 HAMAP MF_01401

Gene names

Name:	msrA2 HAMAP MF_01401
Ordered Locus Names:	Mext_3281

Organism

Methylobacterium extorquens (strain PA1) [Complete proteome] [HAMAP]

Taxonomic identifier

419610 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 SAAS SAAS002569 Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 SAAS SAAS002569
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family. HAMAP MF_01401

Ontologies

Keywords
Molecular function	Oxidoreductase HAMAP MF_01401 SAAS SAAS002569 EMBL ABY31668.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	54	1	By similarity HAMAP MF_01401

Sequences

	Sequence		Length	Mass (Da)
	A9W706 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 14FEF229347D02D7	FASTA	219	23,595
	10 20 30 40 50 60 MLLFRKRPEM PAPSEVLPGR PNPLPTAERH FVNGNPLKGP YPEGVETIVL GLGCFWGAER 70 80 90 100 110 120 KFWELPQGVH VTAVGYAGGT TPNPTYEEVC SGLTGHNEVV LVAYDPAVLP LEAVLKNFFE 130 140 150 160 170 180 SHNPTQGYRQ GNDVGTQYRS GIYTGSETQA ATARAVRDSY AQALDARGYG PITTEIVPLE 190 200 210 TFYFAEEYHQ QYLAKNPGGY CGLGGTGVSC PVGVSVAAE

References

[1]

"Complete sequence of Methylobacterium extorquens PA1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Marx C., Richardson P. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PA1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000908 Genomic DNA. Translation: ABY31668.1.
RefSeq	YP_001640739.1. NC_010172.1.
3D structure databases
ProteinModelPortal	A9W706.
SMR	A9W706. Positions 12-211.
ModBase	Search...
Protein-protein interaction databases
STRING	A9W706.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5835339.
GenomeReviews	Gene locus Mext_3281 in contig CP000908_GR.
KEGG	mex:Mext_3281.
PATRIC	22537160. VBIMetExt98426_3327.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG748152.
OMA	SAIYCTS.
ProtClustDB	CLSK2331629.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A9W706_METEP

Accession

Primary (citable) accession number: A9W706

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)