A9W6X1 (UREF_METEP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Urease accessory protein UreF

Gene names

Name:	ureF
Ordered Locus Names:	Mext_3014

Organism

Methylobacterium extorquens (strain PA1) [Complete proteome] [HAMAP]

Taxonomic identifier

419610 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter By similarity. HAMAP MF_01385
Subunit structure	UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_01385.
Sequence similarities	Belongs to the UreF family.

Ontologies

Keywords
Biological process	Nickel insertion
Cellular component	Cytoplasm
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nickel cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	Urease accessory protein UreF HAMAP MF_01385		PRO_0000344134

Sequences

	Sequence		Length	Mass (Da)
	A9W6X1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 881C5B97FD3355D3	FASTA	244	25,620
	10 20 30 40 50 60 MPAVMPMTTV TDIRTITRTP MIDALRLMAW LSPTYPVGAF AYSHGLEWAV ECGDVRDAAT 70 80 90 100 110 120 LSDWLADVLE WGAGRNDMIL CAAAHRATEA GDDAGLAEIN DLALALAPSR ELHLETSQQG 130 140 150 160 170 180 RSFLDATLRA WPCPALSTVA DRLNAEVAYP VAVGAAAGAH GVARAATVAA YGLAFVQNLV 190 200 210 220 230 240 SAALRVAPVG QSAGTTILAA LTPRVAALAE ALHEAGLDAL GSATLRLDLG SFRHETQYSR IFRS

References

[1]

"Complete sequence of Methylobacterium extorquens PA1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Marx C., Richardson P. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PA1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000908 Genomic DNA. Translation: ABY31403.1.
RefSeq	YP_001640474.1. NC_010172.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A9W6X1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5835399.
GenomeReviews	Gene locus Mext_3014 in contig CP000908_GR.
KEGG	mex:Mext_3014.
PATRIC	22536604. VBIMetExt98426_3051.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG709295.
OMA	WLSPAFP.
ProtClustDB	CLSK2331468.
Enzyme and pathway databases
BioCyc	MEXT419610:MEXT_3014-MONOMER.
Family and domain databases
HAMAP	MF_01385. UreF. [Tree]
InterPro	IPR002639. UreF. [Graphical view]
KO	K03188.
Pfam	PF01730. UreF. 1 hit. [Graphical view]
PIRSF	PIRSF009467. Ureas_acces_UreF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UREF_METEP

Accession

Primary (citable) accession number: A9W6X1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program