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Protein
Submitted name:

3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene

Mext_2991

Organism
Methylobacterium extorquens (strain PA1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.SAAS annotation

Catalytic activityi

D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.SAAS annotation

Pathwayi: riboflavin biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate.SAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 3,4-dihydroxy-2-butanone 4-phosphate synthase (Mext_2991)
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Riboflavin biosynthesisSAAS annotation

Keywords - Ligandi

MagnesiumSAAS annotation, Metal-bindingSAAS annotation

Enzyme and pathway databases

BioCyciMEXT419610:GI32-3041-MONOMER.
UniPathwayiUPA00275; UER00399.

Names & Taxonomyi

Protein namesi
Submitted name:
3,4-dihydroxy-2-butanone 4-phosphate synthaseImported
Gene namesi
Ordered Locus Names:Mext_2991Imported
OrganismiMethylobacterium extorquens (strain PA1)Imported
Taxonomic identifieri419610 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000008546 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi419610.Mext_2991.

Structurei

3D structure databases

ProteinModelPortaliA9W6U8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini229 – 374146GTP_cyclohydro2InterPro annotationAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the DHBP synthase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4105C66. Bacteria.
COG0108. LUCA.
COG0807. LUCA.
HOGENOMiHOG000115440.
KOiK14652.
OMAiSYETAFT.
OrthoDBiEOG679TK8.

Family and domain databases

Gene3Di3.90.870.10. 1 hit.
HAMAPiMF_00180. RibB.
InterProiIPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
IPR032677. GTP_cyclohydro_II.
[Graphical view]
PfamiPF00926. DHBP_synthase. 1 hit.
PF00925. GTP_cyclohydro2. 1 hit.
[Graphical view]
SUPFAMiSSF142695. SSF142695. 1 hit.
SSF55821. SSF55821. 1 hit.
TIGRFAMsiTIGR00506. ribB. 1 hit.

Sequencei

Sequence statusi: Complete.

A9W6U8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGGSSIGVT TLFEPLNETK PVPHCSVTEA IEAFARGEIV VVTDDDDREN
60 70 80 90 100
EGDLVVAASL CTPEKMAFII RNTCGIVCAP ITLDEARRLH LDPMVASNDA
110 120 130 140 150
PLGTAFTVTV DVRHGLTTGI SAEQRCNTVR ALANGNMGAG DFVRPGHVFP
160 170 180 190 200
LIARDGGVLM RSGHTEAAVD LCKLAGLPPV GVICELANDD GTVMKGPQID
210 220 230 240 250
AFSEQHNLKR VSVADLIAYR QARDRLVERV GTFPVKTEFG AMTGYAYVTP
260 270 280 290 300
FEPIQQFAFV HGAIGDGRNM PVRLHRSNVV ADVIEGGGQI ESVMRRFAKE
310 320 330 340 350
GRGILVYLRD GTAGVPLNRY AEEEGAEAQR VRQWREVGLG AQILRDLGVV
360 370 380
SIRNLSSSSR SYVGLSGFGI ELVSDEPLEG
Length:380
Mass (Da):40,799
Last modified:February 5, 2008 - v1
Checksum:iBAD96E7E572BA0F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000908 Genomic DNA. Translation: ABY31380.1.

Genome annotation databases

EnsemblBacteriaiABY31380; ABY31380; Mext_2991.
KEGGimex:Mext_2991.
PATRICi22536554. VBIMetExt98426_3026.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000908 Genomic DNA. Translation: ABY31380.1.

3D structure databases

ProteinModelPortaliA9W6U8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi419610.Mext_2991.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY31380; ABY31380; Mext_2991.
KEGGimex:Mext_2991.
PATRICi22536554. VBIMetExt98426_3026.

Phylogenomic databases

eggNOGiENOG4105C66. Bacteria.
COG0108. LUCA.
COG0807. LUCA.
HOGENOMiHOG000115440.
KOiK14652.
OMAiSYETAFT.
OrthoDBiEOG679TK8.

Enzyme and pathway databases

UniPathwayiUPA00275; UER00399.
BioCyciMEXT419610:GI32-3041-MONOMER.

Family and domain databases

Gene3Di3.90.870.10. 1 hit.
HAMAPiMF_00180. RibB.
InterProiIPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
IPR032677. GTP_cyclohydro_II.
[Graphical view]
PfamiPF00926. DHBP_synthase. 1 hit.
PF00925. GTP_cyclohydro2. 1 hit.
[Graphical view]
SUPFAMiSSF142695. SSF142695. 1 hit.
SSF55821. SSF55821. 1 hit.
TIGRFAMsiTIGR00506. ribB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PA1Imported.

Entry informationi

Entry nameiA9W6U8_METEP
AccessioniPrimary (citable) accession number: A9W6U8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 8, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.