A9W5Y0 (A9W5Y0_METEP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Homoserine kinase HAMAP MF_00301
Short name=HK HAMAP MF_00301
Short name=HSK HAMAP MF_00301
EC=2.7.1.39 HAMAP MF_00301

Gene names

Name:	thrB HAMAP MF_00301
Ordered Locus Names:	Mext_2594

Organism

Methylobacterium extorquens (strain PA1) [Complete proteome] [HAMAP]

Taxonomic identifier

419610 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301 SAAS SAAS002575
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301 SAAS SAAS002575
Sequence similarities	Belongs to the pseudomonas-type thrB family. HAMAP MF_00301

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis HAMAP MF_00301 SAAS SAAS002575
Ligand	ATP-binding HAMAP MF_00301 SAAS SAAS002575 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00301 SAAS SAAS002575 EMBL ABY30986.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A9W5Y0 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 8CB91779EE8B7B2E	FASTA	329	35,754
	10 20 30 40 50 60 MSETGSGTVA VYTDVSDEAL RAFLREYELG ELLSYKGIAE GVENSNFFLH TSTGNYILTL 70 80 90 100 110 120 YEKRVNAADL PFFINLMGHL ARAGLACPQP VRNRAGTALG HLCGRPAAIV TFLEGVSLSR 130 140 150 160 170 180 PNAEHCRALG AALAGLHAAG RDFPMVRANN LSVEAWRPLF VQAEAQADTV SPGLAARTRA 190 200 210 220 230 240 DLDWLEASWP QGLPAGVIHA DLFTDNVFFI GDAVSGLIDF YFACTDAFAY DLAISLNAWC 250 260 270 280 290 300 FDADGTFHRD KAGAMIAGYD AVRALEPAEI AALPILARGA AMRFMLTRLV DWLNVPPGAL 310 320 VQPKDPLEYD RRLGFHRTAT DARDYGWQK

References

[1]

"Complete sequence of Methylobacterium extorquens PA1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Marx C., Richardson P. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PA1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000908 Genomic DNA. Translation: ABY30986.1.
RefSeq	YP_001640057.1. NC_010172.1.
3D structure databases
ProteinModelPortal	A9W5Y0.
SMR	A9W5Y0. Positions 13-327.
ModBase	Search...
Protein-protein interaction databases
STRING	A9W5Y0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5833810.
GenomeReviews	Gene locus Mext_2594 in contig CP000908_GR.
KEGG	mex:Mext_2594.
PATRIC	22535726. VBIMetExt98426_2616.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	CLSK2331237.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A9W5Y0_METEP

Accession

Primary (citable) accession number: A9W5Y0

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)