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A9W5X9 (A9W5X9_METEP) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH HAMAP MF_00191
Ordered Locus Names:Mext_2593
OrganismMethylobacterium extorquens (strain PA1) [Complete proteome] [HAMAP]
Taxonomic identifier419610 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191 SAAS SAAS003451

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191 SAAS SAAS003451

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191 SAAS SAAS003451

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
A9W5X9 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 3AE45949197842B9

FASTA34036,865
        10         20         30         40         50         60 
MSADTINLTA DPNRVPHPAV TGDKPPLEIL LCAPRGFCAG VVRAIDVVER ALAIYGAPVY 

        70         80         90        100        110        120 
VRHEIVHNKY VVETLKRKGA VFVRELDEVP DSGAPVIFSA HGVAKTVPQN ADARGLTTID 

       130        140        150        160        170        180 
ATCPLVTKVH REAEIHHKRG RHVLLVGHSG HPEVVGTMGQ LPKGSITLVE DIDQIDALNP 

       190        200        210        220        230        240 
PADQALAWVT QTTLSIDDTK HIVEALKAKF TGIHGPHKDD ICYATTNRQE AVKEVAPRVD 

       250        260        270        280        290        300 
ALIVVGSSNS SNSQRLREVA ERAGCPITRL VLRAEEIDWD AFKDIRRLGL TAGASAPEVL 

       310        320        330        340 
VEEIIDAFAA RFDVTVDQVS VTVEDMSFPL PRELRSEAAE

« Hide

References

[1]"Complete sequence of Methylobacterium extorquens PA1."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Marx C., Richardson P.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PA1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000908 Genomic DNA. Translation: ABY30985.1.
RefSeqYP_001640056.1. NC_010172.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA9W5X9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5833809.
GenomeReviewsGene locus Mext_2593 in contig CP000908_GR.
KEGGmex:Mext_2593.
PATRIC22535724. VBIMetExt98426_2615.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG335228.
OMAWGAPVYV.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA9W5X9_METEP
AccessionPrimary (citable) accession number: A9W5X9
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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