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A9W5B4

- GLSA_METEP

UniProt

A9W5B4 - GLSA_METEP

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Protein

Glutaminase

Gene

glsA

Organism
Methylobacterium extorquens (strain PA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641SubstrateUniRule annotation
Binding sitei114 – 1141SubstrateUniRule annotation
Binding sitei160 – 1601SubstrateUniRule annotation
Binding sitei167 – 1671SubstrateUniRule annotation
Binding sitei191 – 1911SubstrateUniRule annotation
Binding sitei243 – 2431SubstrateUniRule annotation
Binding sitei261 – 2611Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMEXT419610:GI32-2418-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:Mext_2375
OrganismiMethylobacterium extorquens (strain PA1)
Taxonomic identifieri419610 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000008546: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309GlutaminasePRO_1000119532Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi419610.Mext_2375.

Structurei

3D structure databases

ProteinModelPortaliA9W5B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiQRARRIN.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

A9W5B4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPDLDSIVKD IAAEMRARPD RGAVASYIPE LARVDAQGFG LVVIDGEGRV
60 70 80 90 100
AAGGDADTPF SIQSISKVFT LTLALGMVGD RLWRRVGREP SGSPFNSIVQ
110 120 130 140 150
LEREHGIPRN PFINAGAIAV TDLILSGHQP REALGEILRF MQFVAQDDSI
160 170 180 190 200
TIDERVAASE KRTGFRNAAL ANYMRSFDVI ENPVDYTLGV YFHHCAIAMT
210 220 230 240 250
CRQLATAGLF LAYSGHHPLA GHSVISAERA RRINAIMLTC GHYDGSGDFA
260 270 280 290 300
YRVGLPGKSG VGGGILAVAP GKASICVWSP GLDAAGNSHL GRIALEMLVK

RTGWSIFGV
Length:309
Mass (Da):33,045
Last modified:February 5, 2008 - v1
Checksum:iAF8CCC16BBC3A551
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000908 Genomic DNA. Translation: ABY30770.1.
RefSeqiWP_012253805.1. NC_010172.1.
YP_001639841.1. NC_010172.1.

Genome annotation databases

EnsemblBacteriaiABY30770; ABY30770; Mext_2375.
GeneIDi5831819.
KEGGimex:Mext_2375.
PATRICi22535270. VBIMetExt98426_2391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000908 Genomic DNA. Translation: ABY30770.1 .
RefSeqi WP_012253805.1. NC_010172.1.
YP_001639841.1. NC_010172.1.

3D structure databases

ProteinModelPortali A9W5B4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 419610.Mext_2375.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY30770 ; ABY30770 ; Mext_2375 .
GeneIDi 5831819.
KEGGi mex:Mext_2375.
PATRICi 22535270. VBIMetExt98426_2391.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi QRARRIN.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci MEXT419610:GI32-2418-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PA1.

Entry informationi

Entry nameiGLSA_METEP
AccessioniPrimary (citable) accession number: A9W5B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3