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A9W5B4

- GLSA_METEP

UniProt

A9W5B4 - GLSA_METEP

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Protein
Glutaminase
Gene
glsA, Mext_2375
Organism
Methylobacterium extorquens (strain PA1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641Substrate By similarity
Binding sitei114 – 1141Substrate By similarity
Binding sitei160 – 1601Substrate By similarity
Binding sitei167 – 1671Substrate By similarity
Binding sitei191 – 1911Substrate By similarity
Binding sitei243 – 2431Substrate By similarity
Binding sitei261 – 2611Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMEXT419610:GI32-2418-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:Mext_2375
OrganismiMethylobacterium extorquens (strain PA1)
Taxonomic identifieri419610 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000008546: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309GlutaminaseUniRule annotation
PRO_1000119532Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi419610.Mext_2375.

Structurei

3D structure databases

ProteinModelPortaliA9W5B4.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiQRARRIN.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

A9W5B4-1 [UniParc]FASTAAdd to Basket

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MPDLDSIVKD IAAEMRARPD RGAVASYIPE LARVDAQGFG LVVIDGEGRV    50
AAGGDADTPF SIQSISKVFT LTLALGMVGD RLWRRVGREP SGSPFNSIVQ 100
LEREHGIPRN PFINAGAIAV TDLILSGHQP REALGEILRF MQFVAQDDSI 150
TIDERVAASE KRTGFRNAAL ANYMRSFDVI ENPVDYTLGV YFHHCAIAMT 200
CRQLATAGLF LAYSGHHPLA GHSVISAERA RRINAIMLTC GHYDGSGDFA 250
YRVGLPGKSG VGGGILAVAP GKASICVWSP GLDAAGNSHL GRIALEMLVK 300
RTGWSIFGV 309
Length:309
Mass (Da):33,045
Last modified:February 5, 2008 - v1
Checksum:iAF8CCC16BBC3A551
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000908 Genomic DNA. Translation: ABY30770.1.
RefSeqiYP_001639841.1. NC_010172.1.

Genome annotation databases

EnsemblBacteriaiABY30770; ABY30770; Mext_2375.
GeneIDi5831819.
KEGGimex:Mext_2375.
PATRICi22535270. VBIMetExt98426_2391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000908 Genomic DNA. Translation: ABY30770.1 .
RefSeqi YP_001639841.1. NC_010172.1.

3D structure databases

ProteinModelPortali A9W5B4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 419610.Mext_2375.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY30770 ; ABY30770 ; Mext_2375 .
GeneIDi 5831819.
KEGGi mex:Mext_2375.
PATRICi 22535270. VBIMetExt98426_2391.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi QRARRIN.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci MEXT419610:GI32-2418-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PA1.

Entry informationi

Entry nameiGLSA_METEP
AccessioniPrimary (citable) accession number: A9W5B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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