A9W5A7 (PGK_METEP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycerate kinase
EC=2.7.2.3

Gene names

Name:	pgk
Ordered Locus Names:	Mext_2368

Organism

Methylobacterium extorquens (strain PA1) [Complete proteome] [HAMAP]

Taxonomic identifier

419610 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium › Methylobacterium extorquens group › Methylobacterium extorquens

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145
Subunit structure	Monomer By similarity. HAMAP-Rule MF_00145
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00145.
Sequence similarities	Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycerate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	Phosphoglycerate kinase HAMAP-Rule MF_00145		PRO_1000203340
Regions
	Nucleotide binding	355 – 358	4	ATP By similarity
	Region	23 – 25	3	Substrate binding By similarity
	Region	61 – 64	4	Substrate binding By similarity
Sites
	Binding site	38	1	Substrate By similarity
	Binding site	120	1	Substrate By similarity
	Binding site	153	1	Substrate By similarity
	Binding site	203	1	ATP By similarity
	Binding site	325	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9W5A7 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 003B4822A9088A1C	FASTA	400	41,819
	10 20 30 40 50 60 MTDFRTLDDA GPLQGKRVLL RVDLNVPMEG GRVTDATRIE RVVPTIREIA DAGGRVILLA 70 80 90 100 110 120 HFGRPKGKPD PKDSLKPILS TLSEKLGRPV AFGEDCVGEA AASAIAALKD GDVILLENTR 130 140 150 160 170 180 YHAGEEKNDP DFAKALAANG DIYVNEAFSA AHRAHASTEA LARLLPAYAG RLMQAELDAL 190 200 210 220 230 240 TKGLEAPARP VIAIVGGAKV STKIDLLENL VAKVDMLVIG GGMANTFLHA QGKDVGKSLC 250 260 270 280 290 300 EKDLAETAKR ILAAAKEKNC TIILPVDALV AREFKANAEN ETVPVDAVPS DAMILDVGAS 310 320 330 340 350 360 SIATIDGAIE EARTLVWNGP LGAFELTPFD TGTVAVAQHA ARRTKAGQLV SVAGGGDTVA 370 380 390 400 ALNHAGVGED FSYVSTAGGA FLEWLEGKEL PGVEALRAQG

References

[1]

"Complete sequence of Methylobacterium extorquens PA1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Marx C., Richardson P. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PA1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000908 Genomic DNA. Translation: ABY30763.1.
RefSeq	YP_001639834.1. NC_010172.1.
3D structure databases
ProteinModelPortal	A9W5A7.
ModBase	Search...
Protein-protein interaction databases
STRING	419610.Mext_2368.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABY30763; ABY30763; Mext_2368.
GeneID	5833578.
KEGG	mex:Mext_2368.
PATRIC	22535256. VBIMetExt98426_2384.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0126.
HOGENOM	HOG000227107.
KO	K00927.
OMA	KFGLADK.
ProtClustDB	CLSK2331121.
Enzyme and pathway databases
BioCyc	MEXT419610:GI32-2411-MONOMER.
UniPathway	UPA00109; UER00185.
Family and domain databases
Gene3D	3.40.50.1260. 1 hit. 3.40.50.1270. 1 hit.
HAMAP	MF_00145. Phosphoglyc_kinase.
InterPro	IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. [Graphical view]
PANTHER	PTHR11406. PTHR11406. 1 hit.
Pfam	PF00162. PGK. 1 hit. [Graphical view]
PIRSF	PIRSF000724. Pgk. 1 hit.
PRINTS	PR00477. PHGLYCKINASE.
SUPFAM	SSF53748. PGK. 1 hit.
PROSITE	PS00111. PGLYCERATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGK_METEP

Accession

Primary (citable) accession number: A9W5A7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program