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A9W5A7 (PGK_METEP) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:Mext_2368
OrganismMethylobacterium extorquens (strain PA1) [Complete proteome] [HAMAP]
Taxonomic identifier419610 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 400400Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_1000203340

Regions

Nucleotide binding355 – 3584ATP By similarity
Region23 – 253Substrate binding By similarity
Region61 – 644Substrate binding By similarity

Sites

Binding site381Substrate By similarity
Binding site1201Substrate By similarity
Binding site1531Substrate By similarity
Binding site2031ATP By similarity
Binding site3251ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A9W5A7 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 003B4822A9088A1C

FASTA40041,819
        10         20         30         40         50         60 
MTDFRTLDDA GPLQGKRVLL RVDLNVPMEG GRVTDATRIE RVVPTIREIA DAGGRVILLA 

        70         80         90        100        110        120 
HFGRPKGKPD PKDSLKPILS TLSEKLGRPV AFGEDCVGEA AASAIAALKD GDVILLENTR 

       130        140        150        160        170        180 
YHAGEEKNDP DFAKALAANG DIYVNEAFSA AHRAHASTEA LARLLPAYAG RLMQAELDAL 

       190        200        210        220        230        240 
TKGLEAPARP VIAIVGGAKV STKIDLLENL VAKVDMLVIG GGMANTFLHA QGKDVGKSLC 

       250        260        270        280        290        300 
EKDLAETAKR ILAAAKEKNC TIILPVDALV AREFKANAEN ETVPVDAVPS DAMILDVGAS 

       310        320        330        340        350        360 
SIATIDGAIE EARTLVWNGP LGAFELTPFD TGTVAVAQHA ARRTKAGQLV SVAGGGDTVA 

       370        380        390        400 
ALNHAGVGED FSYVSTAGGA FLEWLEGKEL PGVEALRAQG 

« Hide

References

[1]"Complete sequence of Methylobacterium extorquens PA1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Marx C., Richardson P.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PA1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000908 Genomic DNA. Translation: ABY30763.1.
RefSeqYP_001639834.1. NC_010172.1.

3D structure databases

ProteinModelPortalA9W5A7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING419610.Mext_2368.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABY30763; ABY30763; Mext_2368.
GeneID5833578.
KEGGmex:Mext_2368.
PATRIC22535256. VBIMetExt98426_2384.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OMAVAKEFAP.
OrthoDBEOG64N9Z0.

Enzyme and pathway databases

BioCycMEXT419610:GI32-2411-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_METEP
AccessionPrimary (citable) accession number: A9W5A7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 5, 2008
Last modified: June 11, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways