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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Methylobacterium extorquens (strain PA1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei105Proton acceptorUniRule annotation1
Binding sitei123SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:Mext_2298
OrganismiMethylobacterium extorquens (strain PA1)
Taxonomic identifieri419610 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000008546 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000976741 – 236Ribose-5-phosphate isomerase AAdd BLAST236

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi419610.Mext_2298.

Structurei

3D structure databases

ProteinModelPortaliA9W537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 31Substrate bindingUniRule annotation4
Regioni83 – 86Substrate bindingUniRule annotation4
Regioni96 – 99Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
HOGENOMiHOG000276369.
KOiK01807.
OMAiIFNHQNT.
OrthoDBiPOG091H059I.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

A9W537-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPDLKRAA AERAIPLVED GMRLGIGTGS TAAAFIKLLG ERVRAGLKVT
60 70 80 90 100
GVPTSEATRI ACEREGIPLA TLEDLPELDL TIDGADEVDG SLRLIKGGGA
110 120 130 140 150
ALLREKIVAV ASRRMVVIAD ASKHVETLGA FPLPVEVNLF GIGATTRAVE
160 170 180 190 200
AAVARAGCTG ETVRRHDASG APLLTDGGHA ILDLRLGRIP DPEALSAGLW
210 220 230
AVPGVVEHGL FLGIADAAIL AAAEGDAAVV SVLGRL
Length:236
Mass (Da):24,110
Last modified:February 5, 2008 - v1
Checksum:iA45CC4A3A096189B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000908 Genomic DNA. Translation: ABY30693.1.
RefSeqiWP_012253737.1. NC_010172.1.

Genome annotation databases

EnsemblBacteriaiABY30693; ABY30693; Mext_2298.
KEGGimex:Mext_2298.
PATRICi22535112. VBIMetExt98426_2312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000908 Genomic DNA. Translation: ABY30693.1.
RefSeqiWP_012253737.1. NC_010172.1.

3D structure databases

ProteinModelPortaliA9W537.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi419610.Mext_2298.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY30693; ABY30693; Mext_2298.
KEGGimex:Mext_2298.
PATRICi22535112. VBIMetExt98426_2312.

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
HOGENOMiHOG000276369.
KOiK01807.
OMAiIFNHQNT.
OrthoDBiPOG091H059I.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPIA_METEP
AccessioniPrimary (citable) accession number: A9W537
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 5, 2008
Last modified: November 2, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.