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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Methylobacterium extorquens (strain PA1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei142 – 1421UniRule annotation
Active sitei581 – 5811UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciMEXT419610:GI32-1841-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:Mext_1801Imported
OrganismiMethylobacterium extorquens (strain PA1)Imported
Taxonomic identifieri419610 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000008546: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi419610.Mext_1801.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiNLMIASL.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9W3P4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKTLHARPS AATDTTFAPP VITGTATEDA LEILFHALLD VARRHDPELE
60 70 80 90 100
DVLHGRADIS SFTPEMLARA LQVQGIWFQL VSIAEQNAAM RRRRHVERDQ
110 120 130 140 150
GREALNGSFA KVLAEASARG IGPQQIHALL KDLRIRPTIT AHPTEGKRVT
160 170 180 190 200
VLEKLRRIYL VLRELELPRW TERERNGLMN ELRDQIELIW MTGELHLEKA
210 220 230 240 250
TVEREVAWGL HFFDETLFEM LPEMLLSLEE SLAQYYPDET FEVPPFFQFG
260 270 280 290 300
SWIGGDRDGN PYVTASVTRE TLQRNALASL RRYRDGITHL GRVLSITERS
310 320 330 340 350
LPVPETFRSE LAHMLAESGD ARAIANRNPG EAYRQFLSCV LRKLKATIAR
360 370 380 390 400
NKGARSVGPD YPSADGLIND LRTLEKGLAD AKCGALATDI VRPVRRMVEI
410 420 430 440 450
FRFSTVRLDL RENSTRTTKT LHALWKLRNG DREPPALDSP AWKDWLLTEL
460 470 480 490 500
ARPRTPETSF EDFADRLPDD ARETLATFAL VGEMRDTLDR EAFGAFILSM
510 520 530 540 550
TRSTVDVLGA YLLAKEAGIF LDTTGTEICP LPIVPLFETI DDLRAAPAIM
560 570 580 590 600
KELLGIPVVR RSTRWQGGVQ EVMIGYSDSN KDGGFIASNW ELYKAQVRLT
610 620 630 640 650
TLGNHLGVPI AFFHGRGGSV SRGGVPTHRG IAAQPPGSIQ GRFRITEQGE
660 670 680 690 700
VVSFKYANRG TAAYQMELLA ASVFEHALLS EGNGNGSRAE FDDALEALSG
710 720 730 740 750
ASRAAYVNLL QAEGLVDYFQ AASPLDEISL LNIGSRPARR FGAKSLSDLR
760 770 780 790 800
AIPWVFAWSQ NRHVITGWYG VGSGLKSFID VRGEAGEALL RRLFRDCRVF
810 820 830 840 850
RLVLDEVEKT LLMVDLEIAR DYAGLVEDEG IRARIFGMIE AEYALTREMV
860 870 880 890 900
LRVSGDSELA QRFPQFSERL RGRLPTINQV SREQVELLRR YRSETDEDKR
910 920
EAVKSALLLS INCIAVGFGA TG
Length:922
Mass (Da):103,079
Last modified:February 5, 2008 - v1
Checksum:i4BD01BCA1C469C7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000908 Genomic DNA. Translation: ABY30200.1.
RefSeqiWP_012253366.1. NC_010172.1.
YP_001639271.1. NC_010172.1.

Genome annotation databases

EnsemblBacteriaiABY30200; ABY30200; Mext_1801.
GeneIDi5832923.
KEGGimex:Mext_1801.
PATRICi22534095. VBIMetExt98426_1807.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000908 Genomic DNA. Translation: ABY30200.1.
RefSeqiWP_012253366.1. NC_010172.1.
YP_001639271.1. NC_010172.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi419610.Mext_1801.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY30200; ABY30200; Mext_1801.
GeneIDi5832923.
KEGGimex:Mext_1801.
PATRICi22534095. VBIMetExt98426_1807.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiNLMIASL.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciMEXT419610:GI32-1841-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PA1Imported.

Entry informationi

Entry nameiA9W3P4_METEP
AccessioniPrimary (citable) accession number: A9W3P4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: February 4, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.