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A9W2R5 (A9W2R5_METEP) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase HAMAP MF_00323 RuleBase RU000607
EC=4.99.1.1 HAMAP MF_00323 RuleBase RU000607
Alternative name(s):
Heme synthase HAMAP MF_00323
Protoheme ferro-lyase HAMAP MF_00323
Gene names
Name:hemH HAMAP MF_00323
Ordered Locus Names:Mext_1470
OrganismMethylobacterium extorquens (strain PA1) [Complete proteome] [HAMAP]
Taxonomic identifier419610 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family. HAMAP MF_00323 RuleBase RU004185

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding2261Iron By similarity HAMAP MF_00323
Metal binding3071Iron By similarity HAMAP MF_00323

Sequences

Sequence LengthMass (Da)Tools
A9W2R5 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 63FDEAB40FA1DA7F

FASTA35640,562
        10         20         30         40         50         60 
MNERVEPHTL LRDPVPVAPT ALPPDHPAVR TGRVGVLLMN LGTPEGTSYW PMRRYLKEFL 

        70         80         90        100        110        120 
SDRRVIEVPR LIWWPLLNLI ILTKRPGPKG RDYASIWNNE RDEGPLKTIT RGQCEKLQAA 

       130        140        150        160        170        180 
MGDSVVVDWA MRYGKPEVSL RIQALLDQGC DRILLVPLYP QYAAATSATA CDQAFKALMQ 

       190        200        210        220        230        240 
MRWQPTVRVS PPYHDDPVYI EAMAQSIREG LAKLDFEPEV ILTSFHGVPK SYLLKGDPYH 

       250        260        270        280        290        300 
CQCLKTGRLI REAMGYTPER MRVTFQSRFG NEEWLKPYTD ETVQALAKSG VKRMAIVAPG 

       310        320        330        340        350 
FTADCLETLE ELDGENRHYF EENGGEKYAF IPCLNDSDLG MRVIENVVRR ELQGWI

« Hide

References

[1]"Complete sequence of Methylobacterium extorquens PA1."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Marx C., Richardson P.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PA1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000908 Genomic DNA. Translation: ABY29871.1.
RefSeqYP_001638942.1. NC_010172.1.

3D structure databases

ProteinModelPortalA9W2R5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9W2R5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5835801.
GenomeReviewsGene locus Mext_1470 in contig CP000908_GR.
KEGGmex:Mext_1470.
PATRIC22533419. VBIMetExt98426_1470.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMAIRPAKSA.
ProtClustDBCLSK979865.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA9W2R5_METEP
AccessionPrimary (citable) accession number: A9W2R5
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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