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A9VVH9

- A9VVH9_BACWK

UniProt

A9VVH9 - A9VVH9_BACWK

Protein
Submitted name:

Crossover junction endodeoxyribonuclease RuvC

Gene

BcerKBAB4_5300

Organism
Bacillus weihenstephanensis (strain KBAB4)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.SAAS annotation
    Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity.

    Catalytic activityi

    Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).SAAS annotation

    Cofactori

    Binds 1 magnesium ion per subunit.SAAS annotation

    GO - Molecular functioni

    1. endodeoxyribonuclease activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW
    3. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-KW
    2. DNA repair Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, NucleaseSAAS annotation

    Keywords - Biological processi

    DNA damage, DNA recombinationSAAS annotation, DNA repairSAAS annotation

    Keywords - Ligandi

    MagnesiumSAAS annotation, Metal-bindingSAAS annotation

    Enzyme and pathway databases

    BioCyciBWEI315730:GHRU-5855-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Crossover junction endodeoxyribonuclease RuvCImported
    Gene namesi
    Ordered Locus Names:BcerKBAB4_5300Imported
    Encoded oniPlasmid pBWB403Imported
    OrganismiBacillus weihenstephanensis (strain KBAB4)Imported
    Taxonomic identifieri315730 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000002154: Plasmid pBWB403

    Interactioni

    Protein-protein interaction databases

    STRINGi315730.BcerKBAB4_5300.

    Structurei

    3D structure databases

    ProteinModelPortaliA9VVH9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0817.
    KOiK01159.
    OMAiLMTHIAN.
    OrthoDBiEOG6RG044.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    InterProiIPR012337. RNaseH-like_dom.
    IPR002176. X-over_junc_endoDNase_RuvC.
    [Graphical view]
    PfamiPF02075. RuvC. 1 hit.
    [Graphical view]
    PRINTSiPR00696. RSOLVASERUVC.
    SUPFAMiSSF53098. SSF53098. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9VVH9-1 [UniParc]FASTAAdd to Basket

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    MTSRRFLGLD MSLASAGIAI IDIVDGELRI VHKQRIKTNP KQRHGERLHK    50
    IATELKSILI EYQPFDTIIR EQGFSRFAKT TQALFKVVGV SDLVLRDYAI 100
    VEISPTTIKL VMTGDGKADK KEVEKAVRKI MRLDDDYIFI SDDESDACAI 150
    ILTHLIQNNI IDKGDK 166
    Length:166
    Mass (Da):18,769
    Last modified:February 5, 2008 - v1
    Checksum:i41E6142CB6C6AE0D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000906 Genomic DNA. Translation: ABY46794.1.
    RefSeqiWP_012260031.1. NC_010182.1.
    YP_001642769.1. NC_010182.1.

    Genome annotation databases

    EnsemblBacteriaiABY46794; ABY46794; BcerKBAB4_5300.
    GeneIDi5839968.
    KEGGibwe:BcerKBAB4_5300.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000906 Genomic DNA. Translation: ABY46794.1 .
    RefSeqi WP_012260031.1. NC_010182.1.
    YP_001642769.1. NC_010182.1.

    3D structure databases

    ProteinModelPortali A9VVH9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315730.BcerKBAB4_5300.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY46794 ; ABY46794 ; BcerKBAB4_5300 .
    GeneIDi 5839968.
    KEGGi bwe:BcerKBAB4_5300.

    Phylogenomic databases

    eggNOGi COG0817.
    KOi K01159.
    OMAi LMTHIAN.
    OrthoDBi EOG6RG044.

    Enzyme and pathway databases

    BioCyci BWEI315730:GHRU-5855-MONOMER.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    InterProi IPR012337. RNaseH-like_dom.
    IPR002176. X-over_junc_endoDNase_RuvC.
    [Graphical view ]
    Pfami PF02075. RuvC. 1 hit.
    [Graphical view ]
    PRINTSi PR00696. RSOLVASERUVC.
    SUPFAMi SSF53098. SSF53098. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiA9VVH9_BACWK
    AccessioniPrimary (citable) accession number: A9VVH9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported, PlasmidImported

    External Data

    Dasty 3