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A9VU75 (MRAY_BACWK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:BcerKBAB4_3740
OrganismBacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP]
Taxonomic identifier315730 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000090591

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane52 – 7221Helical; Potential
Transmembrane77 – 9721Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane149 – 16921Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane201 – 22121Helical; Potential
Transmembrane227 – 24721Helical; Potential
Transmembrane253 – 27321Helical; Potential
Transmembrane302 – 32221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A9VU75 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: BDD9EE24041B2049

FASTA32434,851
        10         20         30         40         50         60 
MLEQGLLVTA GVAFLISVAL SPLFIPFLRK LKFGQSIRDE GPKSHQKKSG TPTMGGIVIY 

        70         80         90        100        110        120 
VSMMVTTLIM AIKFNNLGAE VSLLLLVTFG YGLIGFLDDY IKVVKKRNLG LTSKQKLIGQ 

       130        140        150        160        170        180 
LVIAIAFFLI GKGQAFHTYI MIPGTDVKFE LGWAYFVLVL FMLIGGSNAV NLTDGLDGLL 

       190        200        210        220        230        240 
SGTAAIAFGA FSIIAVAQEQ FGVAIFCMAV VGAVLGFLVF NANPAKVFMG DTGSLALGGA 

       250        260        270        280        290        300 
IAAVAILLKQ ELLLVIIGGV FVAETLSVII QVISFKTTGK RVFKMSPLHH HYELCGWSEW 

       310        320 
RVVVTFWSVG FLLAVLGIYI GVWM

« Hide

References

[1]"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity."
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.
Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KBAB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000903 Genomic DNA. Translation: ABY44909.1.
RefSeqYP_001646537.1. NC_010184.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA9VU75.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000080818; EBBACP00000078752; EBBACG00000080809.
GeneID5843952.
GenomeReviewsGene locus BcerKBAB4_3740 in contig CP000903_GR.
KEGGbwe:BcerKBAB4_3740.
PATRIC19012115. VBIBacWei55973_4374.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000001191.
HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycBWEI315730:BCERKBAB4_3740-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. False negative.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BACWK
AccessionPrimary (citable) accession number: A9VU75
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 5, 2008
Last modified: January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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