A9VTJ2 (A9VTJ2_BACWK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GMP reductase HAMAP MF_01511
EC=1.7.1.7 HAMAP MF_01511

Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase HAMAP MF_01511

Gene names

Name:	guaC HAMAP MF_01511
Ordered Locus Names:	BcerKBAB4_5249

Organism

Bacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP] EMBL ABY46392.1

Taxonomic identifier

315730 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_01511 SAAS SAAS005994
Catalytic activity	Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511 SAAS SAAS005994
Sequence similarities	Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. HAMAP MF_01511

Ontologies

Keywords
Ligand	NADP HAMAP MF_01511 SAAS SAAS005994
Molecular function	Oxidoreductase HAMAP MF_01511 SAAS SAAS005994
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	GMP reductase activity Inferred from electronic annotation. Source: HAMAP dihydroorotate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	204 – 227	24	NADP By similarity HAMAP MF_01511
Sites
	Active site	175	1	Thioimidate intermediate By similarity HAMAP MF_01511

Sequences

	Sequence		Length	Mass (Da)
	A9VTJ2 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 30F274D07962D7BF	FASTA	327	36,118
	10 20 30 40 50 60 MENVFDYEDI QLIPAKCIVN SRSECDTTVT LGKHKFKLPV VPANMQTIID ERIATYLAEN 70 80 90 100 110 120 NYFYIMHRFQ PEKRISFIRD MQSRGLIASI SVGVKEDEYE FVQQLAAEQL SPEYITIDIA 130 140 150 160 170 180 HGHSNAVINM IQHIKKHLPE SFVIAGNVGT PEAVRELENA GADATKVGIG PGKVCITKIK 190 200 210 220 230 240 TGFGTGGWQL AALRWCAKAA SKPIIADGGI RTHGDVAKSI RFGATMVMVG SLFAGHEESP 250 260 270 280 290 300 GETIEKDGKL YKEYFGSASE FQKGEKKNVE GKKMFVEHKG SLEDTLIEME QDLQSSISYA 310 320 GGTKLDAIRT VDYVVVKNSI FNGDKVY

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000903 Genomic DNA. Translation: ABY46392.1.
RefSeq	YP_001648020.1. NC_010184.1.
3D structure databases
ProteinModelPortal	A9VTJ2.
SMR	A9VTJ2. Positions 1-321.
ModBase	Search...
Protein-protein interaction databases
STRING	A9VTJ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000079801; EBBACP00000077735; EBBACG00000079792.
GeneID	5845490.
GenomeReviews	Gene locus BcerKBAB4_5249 in contig CP000903_GR.
KEGG	bwe:BcerKBAB4_5249.
PATRIC	19015262. VBIBacWei55973_5917.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000000995.
HOGENOM	HBG298985.
OMA	PDYITID.
ProtClustDB	PRK05458.
Family and domain databases
HAMAP	MF_01511. GMP_reduct_type2. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001295. Dihydroorotate_DH_CS. IPR005994. GMP_reduct2. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00364.
PANTHER	PTHR11911:SF30. PTHR11911:SF30. 1 hit.
Pfam	PF00478. IMPDH. 1 hit. [Graphical view]
PIRSF	PIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMs	TIGR01306. GMP_reduct_2. 1 hit.
PROSITE	PS00912. DHODEHASE_2. 1 hit. PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A9VTJ2_BACWK

Accession

Primary (citable) accession number: A9VTJ2

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)