A9VSU4 (A9VSU4_BACWK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP MF_01543

Gene names

Name:	fhs HAMAP MF_01543
Ordered Locus Names:	BcerKBAB4_1952

Organism

Bacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP] EMBL ABY43183.1

Taxonomic identifier

315730 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	583 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543
Ligand	ATP-binding HAMAP MF_01543 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 EMBL ABY43183.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	92 – 99	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	A9VSU4 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 65D931746CDBCBA6	FASTA	583	62,818
	10 20 30 40 50 60 MQKIQKTDTI SSESIKGGLG YMTTTTTVKS DIEIAQEASM KKIQEIAANL NILEEELEPY 70 80 90 100 110 120 GHYKGKLSLD IFKRLQDEKD GKVVLVTAIN PTPAGEGKST VTVGLGQAFN KIGKKTVIAL 130 140 150 160 170 180 REPSLGPTMG LKGGAAGGGY SQVVPMEDIN LHFTGDIHAI TTANNALAAF IDNHIQQGNT 190 200 210 220 230 240 LGIDTRKIVW KRCVDLNDRA LRNVVIGLGG PVQGVPREDG FDITVASEIM AVFCLATDIQ 250 260 270 280 290 300 DLKSRLSRIV VAYNFSNQPV TVKDLGVEGA LTLLLKDALK PNLVQTLENT PAIIHGGPFA 310 320 330 340 350 360 NIAHGCNSVI ATTMAAKLGD YVITEAGFGA DLGAEKFLDI KARAAGIKPE AVVIVATIRA 370 380 390 400 410 420 LKMHGGVARD QLKEENVDAL AKGMENLQKH VETIQSFGVP FVIAINKFIT DTDAEVAYLQ 430 440 450 460 470 480 EWCNERGYAV SLTEVWEKGG QGGVDLAEKV LKEIEKGENN YAPLYELELP LEEKIRTIAQ 490 500 510 520 530 540 KVYGAKDIEF APKARKQLAQ YEGEGWSNLP ICMAKTQYSL SDDATKLGRP SDFIVTIREL 550 560 570 580 KPSIGAGFIV ALTGTMLTMP GLPKQPAALQ MDVNEDGKAV GLF

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000903 Genomic DNA. Translation: ABY43183.1.
RefSeq	YP_001644811.1. NC_010184.1.
3D structure databases
ProteinModelPortal	A9VSU4.
SMR	A9VSU4. Positions 31-581.
ModBase	Search...
Protein-protein interaction databases
STRING	A9VSU4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000080106; EBBACP00000078040; EBBACG00000080097.
GeneID	5842165.
GenomeReviews	Gene locus BcerKBAB4_1952 in contig CP000903_GR.
KEGG	bwe:BcerKBAB4_1952.
PATRIC	19008473. VBIBacWei55973_2555.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000004414.
HOGENOM	HBG677721.
OMA	EIMAVLC.
ProtClustDB	PRK13505.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A9VSU4_BACWK

Accession

Primary (citable) accession number: A9VSU4

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)