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A9VRT5 (NAMA_BACWK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADPH dehydrogenase

EC=1.6.99.1
Gene names
Name:namA
Ordered Locus Names:BcerKBAB4_1888
OrganismBacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP]
Taxonomic identifier315730 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes By similarity. HAMAP-Rule MF_01614

Catalytic activity

NADPH + acceptor = NADP+ + reduced acceptor. HAMAP-Rule MF_01614

Cofactor

FMN By similarity. HAMAP-Rule MF_01614

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01614

Sequence similarities

Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345NADPH dehydrogenase HAMAP-Rule MF_01614
PRO_1000185864

Regions

Nucleotide binding23 – 275FMN By similarity

Sites

Binding site281Substrate By similarity
Binding site1641Substrate By similarity
Binding site1671Substrate By similarity
Binding site2151FMN By similarity
Binding site3081FMN By similarity

Sequences

Sequence LengthMass (Da)Tools
A9VRT5 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 79DC0CC8BF22FB43

FASTA34538,665
        10         20         30         40         50         60 
MEFQLFSPYT IKDVTLKNRI IMSPMCMYSS ENEDGQVTNF HLVHYGTRAA GQVGLVMIEA 

        70         80         90        100        110        120 
TAVLPEGRIS NKDLGIWDDN LIEGLHKTTT FIHNNGAKAA IQLAHAGRKA ELETDAFAPS 

       130        140        150        160        170        180 
AIPFNDRMKI PVEMNKQQIK ETVSAFQKAA LRSKRAGVDV IELHGAHGYL INEFLSPLSN 

       190        200        210        220        230        240 
KRIDEYGGSP ENRYRFLREI IDAVNEVWNG PLFVRISAND YHPDGLTVQD YVQYTGWMKE 

       250        260        270        280        290        300 
QGVDLIDCSS GAVVPAHIDV YPGYQVQYAK HIKEHVNIAT GAVGLITTGS QAEQILNNNE 

       310        320        330        340 
ADLIFIGREL LRNPYFPRIA ANELGFELKE PYQYRRAPGK IKTNK 

« Hide

References

[1]"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity."
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.
Chem. Biol. Interact. 171:236-249(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KBAB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000903 Genomic DNA. Translation: ABY43120.1.
RefSeqYP_001644748.1. NC_010184.1.

3D structure databases

ProteinModelPortalA9VRT5.
SMRA9VRT5. Positions 4-337.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315730.BcerKBAB4_1888.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABY43120; ABY43120; BcerKBAB4_1888.
GeneID5842101.
KEGGbwe:BcerKBAB4_1888.
PATRIC19008345. VBIBacWei55973_2491.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1902.
HOGENOMHOG000116232.
KOK00356.
OMAWVEDGWN.
OrthoDBEOG60PHD0.
ProtClustDBPRK13523.

Enzyme and pathway databases

BioCycBWEI315730:GHRU-2004-MONOMER.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01614. NamA.
InterProIPR013785. Aldolase_TIM.
IPR023663. NADPH_DH.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
PfamPF00724. Oxidored_FMN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAMA_BACWK
AccessionPrimary (citable) accession number: A9VRT5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 5, 2008
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families