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A9VRT5

- NAMA_BACWK

UniProt

A9VRT5 - NAMA_BACWK

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Protein

NADPH dehydrogenase

Gene

namA

Organism
Bacillus weihenstephanensis (strain KBAB4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes.UniRule annotation

Catalytic activityi

NADPH + acceptor = NADP+ + reduced acceptor.UniRule annotation

Cofactori

FMN.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281SubstrateUniRule annotation
Binding sitei164 – 1641SubstrateUniRule annotation
Binding sitei167 – 1671SubstrateUniRule annotation
Binding sitei215 – 2151FMNUniRule annotation
Binding sitei308 – 3081FMNUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 275FMNUniRule annotation

GO - Molecular functioni

  1. FMN binding Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP
  3. NADPH dehydrogenase activity Source: UniProtKB-HAMAP
  4. pentaerythritol trinitrate reductase activity Source: UniProtKB-EC
  5. trichloro-p-hydroquinone reductive dehalogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to toxic substance Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Detoxification

Keywords - Ligandi

Flavoprotein, FMN, NADP

Enzyme and pathway databases

BioCyciBWEI315730:GHRU-2004-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH dehydrogenaseUniRule annotation (EC:1.6.99.1UniRule annotation)
Gene namesi
Name:namAUniRule annotation
Ordered Locus Names:BcerKBAB4_1888
OrganismiBacillus weihenstephanensis (strain KBAB4)
Taxonomic identifieri315730 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002154: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345NADPH dehydrogenasePRO_1000185864Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi315730.BcerKBAB4_1888.

Structurei

3D structure databases

ProteinModelPortaliA9VRT5.
SMRiA9VRT5. Positions 4-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1902.
HOGENOMiHOG000116232.
KOiK00356.
OMAiPWLGKHG.
OrthoDBiEOG60PHD0.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01614. NamA.
InterProiIPR013785. Aldolase_TIM.
IPR023663. NADPH_DH.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
PfamiPF00724. Oxidored_FMN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9VRT5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFQLFSPYT IKDVTLKNRI IMSPMCMYSS ENEDGQVTNF HLVHYGTRAA
60 70 80 90 100
GQVGLVMIEA TAVLPEGRIS NKDLGIWDDN LIEGLHKTTT FIHNNGAKAA
110 120 130 140 150
IQLAHAGRKA ELETDAFAPS AIPFNDRMKI PVEMNKQQIK ETVSAFQKAA
160 170 180 190 200
LRSKRAGVDV IELHGAHGYL INEFLSPLSN KRIDEYGGSP ENRYRFLREI
210 220 230 240 250
IDAVNEVWNG PLFVRISAND YHPDGLTVQD YVQYTGWMKE QGVDLIDCSS
260 270 280 290 300
GAVVPAHIDV YPGYQVQYAK HIKEHVNIAT GAVGLITTGS QAEQILNNNE
310 320 330 340
ADLIFIGREL LRNPYFPRIA ANELGFELKE PYQYRRAPGK IKTNK
Length:345
Mass (Da):38,665
Last modified:February 5, 2008 - v1
Checksum:i79DC0CC8BF22FB43
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000903 Genomic DNA. Translation: ABY43120.1.
RefSeqiYP_001644748.1. NC_010184.1.

Genome annotation databases

EnsemblBacteriaiABY43120; ABY43120; BcerKBAB4_1888.
GeneIDi5842101.
KEGGibwe:BcerKBAB4_1888.
PATRICi19008345. VBIBacWei55973_2491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000903 Genomic DNA. Translation: ABY43120.1 .
RefSeqi YP_001644748.1. NC_010184.1.

3D structure databases

ProteinModelPortali A9VRT5.
SMRi A9VRT5. Positions 4-337.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315730.BcerKBAB4_1888.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY43120 ; ABY43120 ; BcerKBAB4_1888 .
GeneIDi 5842101.
KEGGi bwe:BcerKBAB4_1888.
PATRICi 19008345. VBIBacWei55973_2491.

Phylogenomic databases

eggNOGi COG1902.
HOGENOMi HOG000116232.
KOi K00356.
OMAi PWLGKHG.
OrthoDBi EOG60PHD0.

Enzyme and pathway databases

BioCyci BWEI315730:GHRU-2004-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01614. NamA.
InterProi IPR013785. Aldolase_TIM.
IPR023663. NADPH_DH.
IPR001155. OxRdtase_FMN_N.
[Graphical view ]
Pfami PF00724. Oxidored_FMN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KBAB4.

Entry informationi

Entry nameiNAMA_BACWK
AccessioniPrimary (citable) accession number: A9VRT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 5, 2008
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3