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A9VRT5

- NAMA_BACWK

UniProt

A9VRT5 - NAMA_BACWK

Protein

NADPH dehydrogenase

Gene

namA

Organism
Bacillus weihenstephanensis (strain KBAB4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes.UniRule annotation

    Catalytic activityi

    NADPH + acceptor = NADP+ + reduced acceptor.UniRule annotation

    Cofactori

    FMN.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei28 – 281SubstrateUniRule annotation
    Binding sitei164 – 1641SubstrateUniRule annotation
    Binding sitei167 – 1671SubstrateUniRule annotation
    Binding sitei215 – 2151FMNUniRule annotation
    Binding sitei308 – 3081FMNUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 275FMNUniRule annotation

    GO - Molecular functioni

    1. FMN binding Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP
    3. NADPH dehydrogenase activity Source: UniProtKB-HAMAP
    4. pentaerythritol trinitrate reductase activity Source: UniProtKB-EC
    5. trichloro-p-hydroquinone reductive dehalogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to toxic substance Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Detoxification

    Keywords - Ligandi

    Flavoprotein, FMN, NADP

    Enzyme and pathway databases

    BioCyciBWEI315730:GHRU-2004-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADPH dehydrogenaseUniRule annotation (EC:1.6.99.1UniRule annotation)
    Gene namesi
    Name:namAUniRule annotation
    Ordered Locus Names:BcerKBAB4_1888
    OrganismiBacillus weihenstephanensis (strain KBAB4)
    Taxonomic identifieri315730 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000002154: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 345345NADPH dehydrogenasePRO_1000185864Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi315730.BcerKBAB4_1888.

    Structurei

    3D structure databases

    ProteinModelPortaliA9VRT5.
    SMRiA9VRT5. Positions 4-337.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1902.
    HOGENOMiHOG000116232.
    KOiK00356.
    OMAiPWLGKHG.
    OrthoDBiEOG60PHD0.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01614. NamA.
    InterProiIPR013785. Aldolase_TIM.
    IPR023663. NADPH_DH.
    IPR001155. OxRdtase_FMN_N.
    [Graphical view]
    PfamiPF00724. Oxidored_FMN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9VRT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFQLFSPYT IKDVTLKNRI IMSPMCMYSS ENEDGQVTNF HLVHYGTRAA    50
    GQVGLVMIEA TAVLPEGRIS NKDLGIWDDN LIEGLHKTTT FIHNNGAKAA 100
    IQLAHAGRKA ELETDAFAPS AIPFNDRMKI PVEMNKQQIK ETVSAFQKAA 150
    LRSKRAGVDV IELHGAHGYL INEFLSPLSN KRIDEYGGSP ENRYRFLREI 200
    IDAVNEVWNG PLFVRISAND YHPDGLTVQD YVQYTGWMKE QGVDLIDCSS 250
    GAVVPAHIDV YPGYQVQYAK HIKEHVNIAT GAVGLITTGS QAEQILNNNE 300
    ADLIFIGREL LRNPYFPRIA ANELGFELKE PYQYRRAPGK IKTNK 345
    Length:345
    Mass (Da):38,665
    Last modified:February 5, 2008 - v1
    Checksum:i79DC0CC8BF22FB43
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000903 Genomic DNA. Translation: ABY43120.1.
    RefSeqiYP_001644748.1. NC_010184.1.

    Genome annotation databases

    EnsemblBacteriaiABY43120; ABY43120; BcerKBAB4_1888.
    GeneIDi5842101.
    KEGGibwe:BcerKBAB4_1888.
    PATRICi19008345. VBIBacWei55973_2491.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000903 Genomic DNA. Translation: ABY43120.1 .
    RefSeqi YP_001644748.1. NC_010184.1.

    3D structure databases

    ProteinModelPortali A9VRT5.
    SMRi A9VRT5. Positions 4-337.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315730.BcerKBAB4_1888.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY43120 ; ABY43120 ; BcerKBAB4_1888 .
    GeneIDi 5842101.
    KEGGi bwe:BcerKBAB4_1888.
    PATRICi 19008345. VBIBacWei55973_2491.

    Phylogenomic databases

    eggNOGi COG1902.
    HOGENOMi HOG000116232.
    KOi K00356.
    OMAi PWLGKHG.
    OrthoDBi EOG60PHD0.

    Enzyme and pathway databases

    BioCyci BWEI315730:GHRU-2004-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01614. NamA.
    InterProi IPR013785. Aldolase_TIM.
    IPR023663. NADPH_DH.
    IPR001155. OxRdtase_FMN_N.
    [Graphical view ]
    Pfami PF00724. Oxidored_FMN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KBAB4.

    Entry informationi

    Entry nameiNAMA_BACWK
    AccessioniPrimary (citable) accession number: A9VRT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3