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A9VRN3

- THIM_BACWK

UniProt

A9VRN3 - THIM_BACWK

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Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Bacillus weihenstephanensis (strain KBAB4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451Substrate; via amide nitrogenUniRule annotation
Binding sitei121 – 1211ATPUniRule annotation
Binding sitei167 – 1671ATPUniRule annotation
Binding sitei194 – 1941Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBWEI315730:GHRU-430-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
Short name:
TH kinaseUniRule annotation
Short name:
Thz kinaseUniRule annotation
Gene namesi
Name:thiMUniRule annotation
Ordered Locus Names:BcerKBAB4_0357
OrganismiBacillus weihenstephanensis (strain KBAB4)
Taxonomic identifieri315730 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002154: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Hydroxyethylthiazole kinasePRO_1000100409Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315730.BcerKBAB4_0357.

Structurei

3D structure databases

ProteinModelPortaliA9VRN3.
SMRiA9VRN3. Positions 1-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiQTFTANV.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

A9VRN3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNMKEISKVV DLVRESNPLV HNITNVVVTN FTANGLLALG ASPVMAYAKE
60 70 80 90 100
EVAEMASIAG ALVLNMGTLR PEEVEAMLLA GKSANKNDVP VLFDPVGAGA
110 120 130 140 150
TSYRTEVARY IPAEIDLAVI RGNAAEIANV INEKWEIKGV DAGTGNGNVV
160 170 180 190 200
NIAKQAADEL NTVAVITGQE DVVTDGERTI LIRNGHPILT KVTGTGCLLT
210 220 230 240 250
SVIGAFVAVE KDYVKAAVAA LTFYGVAAEI AASKTVENGP GSFQIEFLNQ
260
LANTTSDDIE KYGKIEVIQ
Length:269
Mass (Da):28,328
Last modified:February 5, 2008 - v1
Checksum:iD51B44CE717EF477
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000903 Genomic DNA. Translation: ABY41623.1.
RefSeqiYP_001643251.1. NC_010184.1.

Genome annotation databases

EnsemblBacteriaiABY41623; ABY41623; BcerKBAB4_0357.
GeneIDi5840527.
KEGGibwe:BcerKBAB4_0357.
PATRICi19005118. VBIBacWei55973_0923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000903 Genomic DNA. Translation: ABY41623.1 .
RefSeqi YP_001643251.1. NC_010184.1.

3D structure databases

ProteinModelPortali A9VRN3.
SMRi A9VRN3. Positions 1-268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315730.BcerKBAB4_0357.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY41623 ; ABY41623 ; BcerKBAB4_0357 .
GeneIDi 5840527.
KEGGi bwe:BcerKBAB4_0357.
PATRICi 19005118. VBIBacWei55973_0923.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi QTFTANV.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci BWEI315730:GHRU-430-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KBAB4.

Entry informationi

Entry nameiTHIM_BACWK
AccessioniPrimary (citable) accession number: A9VRN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 5, 2008
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3