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A9VPX5 (LEXA_BACWK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
LexA repressor

EC=3.4.21.88
Gene names
Name:lexA
Ordered Locus Names:BcerKBAB4_3377
OrganismBacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP]
Taxonomic identifier315730 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair By similarity. HAMAP MF_00015

Catalytic activity

Hydrolysis of Ala-|-Gly bond in repressor lexA. HAMAP MF_00015

Subunit structure

Homodimer By similarity. HAMAP MF_00015

Sequence similarities

Belongs to the peptidase S24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 204204LexA repressor HAMAP MF_00015
PRO_1000089545

Regions

DNA binding28 – 4821H-T-H motif By similarity

Sites

Active site1261For autocatalytic cleavage activity By similarity
Active site1641For autocatalytic cleavage activity By similarity
Site90 – 912Cleavage; by autolysis By similarity

Sequences

Sequence LengthMass (Da)Tools
A9VPX5 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 5C98C94FBEE03BA1

FASTA20422,629
        10         20         30         40         50         60 
MEKLTKRQQD ILDFIKLKVQ EKGYPPSVRE IGQAVGLASS STVHGHLSRL EEKGYIRRDP 

        70         80         90        100        110        120 
TKPRAIEILG DNRTETQSVI QVPIIGKVTA GLPITAVESV EDHFPLPASI VAGADQVFML 

       130        140        150        160        170        180 
RISGDSMIEA GIFDGDLVVV RQQQSAYNGE IVVALTEDNE ATVKRFYKEK DHFRLQPENS 

       190        200 
SLEPIILKQV SVIGKVIGVY RDLH 

« Hide

References

[1]"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity."
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.
Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KBAB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000903 Genomic DNA. Translation: ABY44551.1.
RefSeqYP_001646179.1. NC_010184.1.

3D structure databases

ProteinModelPortalA9VPX5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9VPX5.

Protein family/group databases

MEROPSS24.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000077853; EBBACP00000075787; EBBACG00000077844.
GeneID5843589.
GenomeReviewsGene locus BcerKBAB4_3377 in contig CP000903_GR.
KEGGbwe:BcerKBAB4_3377.
PATRIC19011383. VBIBacWei55973_4008.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000002279.
HOGENOMHBG679610.
OMATIKRFFK.
ProtClustDBPRK00215.

Enzyme and pathway databases

BioCycBWEI315730:BCERKBAB4_3377-MONOMER.

Family and domain databases

HAMAPMF_00015. LexA.
[Tree]
InterProIPR006199. LexA_DNA-bd_dom.
IPR006200. Pept_S24_LexA.
IPR006197. Peptidase_S24_LexA.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR011056. Peptidase_S24_S26A/B/C_b-rbn.
IPR011991. WHTH_trsnscrt_rep_DNA-bd.
[Graphical view]
Gene3DG3DSA:2.10.109.10. Pept_S24_S26_C. 1 hit.
G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
KOK01356.
PfamPF01726. LexA_DNA_bind. 1 hit.
PF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSPR00726. LEXASERPTASE.
SUPFAMSSF51306. Pept_S24_S26_C. 1 hit.
TIGRFAMsTIGR00498. LexA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLEXA_BACWK
AccessionPrimary (citable) accession number: A9VPX5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 5, 2008
Last modified: January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families