Reviewed,
UniProtKB/Swiss-Prot A9VPX5 (LEXA_BACWK)
Last modified
November 3, 2009.
Version 17.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: LexA repressor EC=3.4.21.88 | ||||
| Gene names |
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| Organism | Bacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 315730 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group |
Protein attributes
| Sequence length | 204 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, leading to derepression of the SOS regulon and eventually DNA repair By similarity. |
| Catalytic activity | Hydrolysis of Ala-|-Gly bond in repressor lexA. HAMAP MF_00015 |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the peptidase S24 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA damage DNA repair DNA replication SOS response Transcription Transcription regulation |
| Ligand | DNA-binding |
| Molecular function | Hydrolase Repressor |
| PTM | Autocatalytic cleavage |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA repair Inferred from electronic annotation. Source: HAMAP DNA replicationInferred from electronic annotation. Source: HAMAP SOS responseInferred from electronic annotation. Source: HAMAP negative regulation of transcription, DNA-dependentInferred from electronic annotation. Source: HAMAP proteolysisInferred from electronic annotation. Source: InterPro transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | DNA binding Inferred from electronic annotation. Source: HAMAP serine-type endopeptidase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 204 | 204 | LexA repressor HAMAP MF_00015 | PRO_1000089545 | |||||
Regions | |||||||||
| DNA binding | 28 – 48 | 21 | H-T-H motif By similarity | ||||||
Sites | |||||||||
| Active site | 126 | 1 | For autocatalytic cleavage activity By similarity | ||||||
| Active site | 164 | 1 | For autocatalytic cleavage activity By similarity | ||||||
| Site | 90 – 91 | 2 | Cleavage; by autolysis By similarity | ||||||
Sequences
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References
| [1] | "Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CP000903 Genomic DNA. Translation: ABY44551.1. | |
| RefSeq | YP_001646179.1. |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | S24.001. |
Genome annotation databases | |
| GeneID | 5843589. |
| GenomeReviews | Gene locus BcerKBAB4_3377 in contig CP000903_GR. |
| KEGG | bwe:BcerKBAB4_3377. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| OMA | KVIGVFR. |
Family and domain databases | |
| HAMAP | MF_00015. [Tree] |
| InterPro | IPR006199. LexA_DNA_bd. IPR006200. Pept_S24_LexA. IPR006197. Peptidase_S24_LexA_cons-reg. IPR019759. Peptidase_S24_S26_cons-reg. IPR011056. Peptidase_S24_S26A/B/C_b-rbn. IPR011991. Wing_hlx_DNA_bd. [Graphical view] |
| Gene3D | G3DSA:2.10.109.10. Pept_S24_S26_C. 1 hit. G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit. |
| Pfam | PF01726. LexA_DNA_bind. 1 hit. PF00717. Peptidase_S24. 1 hit. [Graphical view] |
| PRINTS | PR00726. LEXASERPTASE. |
| TIGRFAMs | TIGR00498. lexA. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | LEXA_BACWK | ||||||||
| Accession | Primary (citable) accession number: A9VPX5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


