Reviewed, UniProtKB/Swiss-Prot A9VMC6 (AROB_BACWK)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	BcerKBAB4_1441

Organism

Bacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP]

Taxonomic identifier

315730 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. NAD By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000094459

Sequences

	Sequence		Length	Mass (Da)
	A9VMC6-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 14A3A3379336140A	FASTA	361	40,256
	10 20 30 40 50 60 MENIHIQTKS KEYDVHVGRE ALSHLTTLIQ KMNPAVSNIM IISDEAVASL HLQTAVDALQ 70 80 90 100 110 120 VEQKVFSFVV PSGEKEKSFE NFYEAHTSAL ENKLDRNSLI IALGGGMIGD LAGFVAASFM 130 140 150 160 170 180 RGIRFVQVPT TLLAHDSAVG GKVAINHPLG KNMIGAFHQP EAVVYHTPFL HSLPEKEWRS 190 200 210 220 230 240 GYAEVIKHAL IGDVELYHWL KEEVQTLTDL RDEKLIHILT KAIPVKANIV SQDETEKGIR 250 260 270 280 290 300 AHLNFGHTLG HALEKELGYG NITHGDGVAV GMLFAMFLSE QVYKVDLSYE EMKQWFLKYG 310 320 330 340 350 360 YPKMPSDLNV ERLVQLMKQD KKANAGTIHM VLMQEYGGVN VVSISDETVH IALEAFQKDM V

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000903 Genomic DNA. Translation: ABY42688.1.
RefSeq	YP_001644316.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5841655.
GenomeReviews	Gene locus BcerKBAB4_1441 in contig CP000903_GR.
KEGG	bwe:BcerKBAB4_1441.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	KANIVAQ.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_BACWK

Accession

Primary (citable) accession number: A9VMC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 5, 2008
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)