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Reviewed, UniProtKB/Swiss-Prot A9VKJ7 (MURC_BACWK)

Last modified November 3, 2009. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    UDP-N-acetylmuramate--L-alanine ligase
    EC=6.3.2.8
Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetase
Gene names
Name: murC
Ordered Locus Names: BcerKBAB4_4518
OrganismBacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP]
Taxonomic identifier315730 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Cell wall formation By similarity.

Catalytic activity

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the murCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046
PRO_1000091077

Regions

Nucleotide binding108 – 1147ATP Potential

Sequences

Sequence LengthMass (Da)Tools
A9VKJ7-1 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: B019539A0A1DAF0F

FASTA43649,260
        10         20         30         40         50         60 
MTVYHFVGIK GTGMSSLAQI LHDMKHTVQG SDYEKRFFTQ TALEKRGISI LPFDKNNIKE 

        70         80         90        100        110        120 
GQVIIAGNAF PDTHEEIVAA KELNIPVHRY HHFLGDLMNQ YTSVAVTGAH GKTSTTGLLA 

       130        140        150        160        170        180 
HVMQGAHPTS YLIGDGTGHG VENSKYFVFE ACEYRRHFLS YYPDYAIMTN IDFDHPDYFA 

       190        200        210        220        230        240 
DINDVFNAFQ EMALQVKKGI IACGDDEELQ KVQAKVPVIF YGFGEDNDFQ ARNIQKRTDG 

       250        260        270        280        290        300 
TIFDVFVRNT YYDTFKITGY GDHSVLNALA VIALCHYENV DVEAVKHQLT TFEGVKRRFN 

       310        320        330        340        350        360 
EKPMGEQVII DDYAHHPTEI NATIEAARQK HPEREVVAVF QPHTFSRTEK FLDEFAESLS 

       370        380        390        400        410        420 
KADQVYLCDI FGSARENKGE LTIEDLQKRI DGAELITDTT TDVLKKHKNG VLIFMGAGDI 

       430 
QKFEAAYVKE VQVAEK 

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References

[1]"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity."
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.
Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

CP000903 Genomic DNA. Translation: ABY45674.1.
RefSeqYP_001647302.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID5844733.
GenomeReviewsGene locus BcerKBAB4_4518 in contig CP000903_GR.
KEGGbwe:BcerKBAB4_4518.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAEWMVVEA.

Family and domain databases

HAMAPMF_00046.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
TIGRFAMsTIGR01082. murC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURC_BACWK
AccessionPrimary (citable) accession number: A9VKJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 5, 2008
Last modified: November 3, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents