A9VJX9 (ODO1_BACWK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-oxoglutarate dehydrogenase E1 component
EC=1.2.4.2

Alternative name(s):
Alpha-ketoglutarate dehydrogenase

Gene names

Name:	odhA
Ordered Locus Names:	BcerKBAB4_1166

Organism

Bacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP]

Taxonomic identifier

315730 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › Bacillus weihenstephanensis

Protein attributes

Sequence length	955 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169
Cofactor	Thiamine pyrophosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: HAMAP thiamine pyrophosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 955	955	2-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169		PRO_1000137970

Sequences

	Sequence		Length	Mass (Da)
	A9VJX9 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 3D6FE7F479FFCC53	FASTA	955	106,226
	10 20 30 40 50 60 MTRKNTTTNP WAKFHGPNLG YVIEQYDLYV TGAGSVDPEL QELFEIFGAP SFQDDVVTGD 70 80 90 100 110 120 NTATHFSPQN TGNIEKILKV VQLVEQIRSF GHTLAHINPM EDAANGQSLI EKTMNELSDA 130 140 150 160 170 180 DLKAIPAKTV WQDAPEGIHT ALDVIHRLKD VYTKSLAYEF SHIQDSEERA WLHQMVESNS 190 200 210 220 230 240 LRQPLSNKKR TALLKRLTAV EGFEQFLHKT FVGQKRFSIE GVDMLVPVLD EIVSEGAKGG 250 260 270 280 290 300 VEDVMIGMAH RGRLSVLAHV LEKPYSHMFA EFKHAKIEGA VANAGWTGDV KYHLGREQVV 310 320 330 340 350 360 GNEEVSTRVT LANNPSHLEF VNPVVEGFAR AAQENRKKSG LPEQDTTKSF VILVHGDAAF 370 380 390 400 410 420 PGQGVVSETL NLSRLNAYQT GGTIHVIANN AVGFTTDSYD SRSTKYSSDL AKGFDIPIVH 430 440 450 460 470 480 VNADDPEACL AAANLAIQYR TLFKKDFLID LIGYRRYGHN EMDDPAVTQP QVYKKIKNHP 490 500 510 520 530 540 TVRAIYADQL QSAGVLNADE VETITQFMQE ELKAEYAQVP PADTSAATIH VKVPEVVAKG 550 560 570 580 590 600 IQPIDTGVSI ESLRAINEGL LSWPEGFNVY PKVKKILERR KDALEENGKI EWALAESLAF 610 620 630 640 650 660 ASILQEGTPI RLTGQDSQRG TFAHRHIVLH DTDTNETYSP LHRLPNINAS FSVHNSPLSE 670 680 690 700 710 720 AAVVGYEYGY NVFAPETLVM WEAQYGDFSN TAQALFDQYV SAGRAKWGQK SGLVLLLPHG 730 740 750 760 770 780 YEGQGPEHSS ARPERFLQLA AENNWTVANL TSAAQYFHIL RRQASILGTE AVRPLVLMTP 790 800 810 820 830 840 KSLLRHPLTL STASQLSEGR FQPALEQENL GAKPNKVKRL VLSTGKMAID LAAEIESGKH 850 860 870 880 890 900 EYSLDEVHMV RVEQLYPFPA EKVQSIIKRF KNLEEIIWVQ EEPRNMGAWH YMAPILFELA 910 920 930 940 950 GDKVKTGYIG RPDRSSPSGG DPFAHKAEQE LIVAHALDVK YNFRQDKQEI EVFSN

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KBAB4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000903 Genomic DNA. Translation: ABY42415.1.
RefSeq	YP_001644043.1. NC_010184.1.
3D structure databases
ProteinModelPortal	A9VJX9.
ModBase	Search...
Protein-protein interaction databases
STRING	315730.BcerKBAB4_1166.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABY42415; ABY42415; BcerKBAB4_1166.
GeneID	5841378.
KEGG	bwe:BcerKBAB4_1166.
PATRIC	19006858. VBIBacWei55973_1750.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0567.
HOGENOM	HOG000259588.
KO	K00164.
OMA	IIKRGGA.
ProtClustDB	PRK09404.
Enzyme and pathway databases
BioCyc	BWEI315730:GHRU-1281-MONOMER.
Family and domain databases
HAMAP	MF_01169. SucA_OdhA.
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR023784. 2oxoglutarate_DH_E1_bac. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
PANTHER	PTHR23152. PTHR23152. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_BACWK

Accession

Primary (citable) accession number: A9VJX9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program