A9VJW0 (TRPC_BACWK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	BcerKBAB4_1147

Organism

Bacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP]

Taxonomic identifier

315730 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000095849

Sequences

	Sequence		Length	Mass (Da)
	A9VJW0 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 8DCCD243E18BD6CF	FASTA	253	28,309
	10 20 30 40 50 60 MGTILDKIVE QKKVEVAELY ETYSPVKEKR KTHSLVKALE QFTVIAEVKR ASPSKGDINL 70 80 90 100 110 120 HVDVPKQVKT YEECGAGAVS VLTDGQFFKG SFHDLETARA ESNIPLLCKD FIIDKIQIDR 130 140 150 160 170 180 AYEAGADLIL LIVAALSKEK LNELYNYVLE KGLEAIVEVH DEQELEIAIR LNPHVIGINN 190 200 210 220 230 240 RNLKTFEVDL SQTEKLGKRL NEENLLWISE SGIHSKEDII RVKRAGAKGV LVGEALMTSS 250 SISNFFEDCK VNI

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KBAB4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000903 Genomic DNA. Translation: ABY42396.1.
RefSeq	YP_001644024.1. NC_010184.1.
3D structure databases
ProteinModelPortal	A9VJW0.
ModBase	Search...
Protein-protein interaction databases
STRING	A9VJW0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000080721; EBBACP00000078655; EBBACG00000080712.
GeneID	5841359.
GenomeReviews	Gene locus BcerKBAB4_1147 in contig CP000903_GR.
KEGG	bwe:BcerKBAB4_1147.
PATRIC	19006818. VBIBacWei55973_1730.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000001798.
HOGENOM	HBG540956.
OMA	VESLGMT.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	BWEI315730:BCERKBAB4_1147-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BACWK

Accession

Primary (citable) accession number: A9VJW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program