A9VJS5 (PRPE_BACWK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase prpE [asymmetrical]
EC=3.6.1.17

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase
Short name=Diadenosine tetraphosphatase

Gene names

Name:	prpE
Ordered Locus Names:	BcerKBAB4_1112

Organism

Bacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP]

Taxonomic identifier

315730 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Asymmetrically hydrolyzes Ap4p to yield AMP and ATP By similarity. HAMAP MF_01443
Catalytic activity	P1,P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP. HAMAP MF_01443
Cofactor	Nickel By similarity. HAMAP MF_01443
Sequence similarities	Belongs to the prpE family.

Ontologies

Keywords
Ligand	Nickel
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity Inferred from electronic annotation. Source: EC nickel cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Bis(5'-nucleosyl)-tetraphosphatase prpE [asymmetrical] HAMAP MF_01443		PRO_1000145931

Sequences

	Sequence		Length	Mass (Da)
	A9VJS5 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 5C2FCA5F7DF67F92	FASTA	246	28,184
	10 20 30 40 50 60 MKYDIIGDIH GCFQEFQDLT TKLGYSWDSG IPIHNAKRRL AFVGDITDRG PHSLRMIEIV 70 80 90 100 110 120 WELVINRKDA YYAPGNHCNK LYRFFLGRNV TIAHGLETTV AEYEALPSNK QQIIKEKFIT 130 140 150 160 170 180 LYEQSPLYHI LDEKNLTVCH AGIRQDYIGR QDKKVQTFVL YGDITGEKHP DGSPVRQDWA 190 200 210 220 230 240 KEYKGETWIV YGHTPVNEPR FVNHTVNIDT GAVFGGKLTG LRYPELETVS VPSSLPFVPE KFRPIS

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KBAB4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000903 Genomic DNA. Translation: ABY42361.1.
RefSeq	YP_001643989.1. NC_010184.1.
3D structure databases
ProteinModelPortal	A9VJS5.
ModBase	Search...
Protein-protein interaction databases
STRING	A9VJS5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000080557; EBBACP00000078491; EBBACG00000080548.
GeneID	5841324.
GenomeReviews	Gene locus BcerKBAB4_1112 in contig CP000903_GR.
KEGG	bwe:BcerKBAB4_1112.
PATRIC	19006746. VBIBacWei55973_1694.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000002430.
HOGENOM	HBG724457.
OMA	YVPGNHC.
ProtClustDB	PRK13625.
Enzyme and pathway databases
BioCyc	BWEI315730:BCERKBAB4_1112-MONOMER.
Family and domain databases
HAMAP	MF_01443. PrpE. [Tree]
InterPro	IPR023937. Bis(5'-nucleosyl)-tetraP_PrpE. IPR004843. Metallo_PEstase_dom. [Graphical view]
KO	K01090.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PRPE_BACWK

Accession

Primary (citable) accession number: A9VJS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program