A9VIT5 (GSA2_BACWK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase 2
Short name=GSA 2
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase 2
Short name=GSA-AT 2

Gene names

Name:	hemL2
Ordered Locus Names:	BcerKBAB4_4306

Organism

Bacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP]

Taxonomic identifier

315730 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › Bacillus weihenstephanensis

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375
Cofactor	Pyridoxal phosphate By similarity. HAMAP-Rule MF_00375
Pathway	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_00375
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00375.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: HAMAP protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	Glutamate-1-semialdehyde 2,1-aminomutase 2 HAMAP-Rule MF_00375		PRO_0000382282
Amino acid modifications
	Modified residue	268	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9VIT5 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 566C7AC7B4D875DC	FASTA	429	46,108
	10 20 30 40 50 60 MKKFDKSIAA FEEAQNLMPG GVNSPVRAFK SVGMNPLFME RGKGSKVYDI DGNEYIDYVL 70 80 90 100 110 120 SWGPLIHGHA NDRVVEALKA VAEKGTSFGA PTEIENKLAQ LVIERVPSIE IVRMVNSGTE 130 140 150 160 170 180 ATMSALRLAR GYTGRNKILK FIGCYHGHGD SLLIKAGSGV ATLGLPDSPG VPEGVAKNTI 190 200 210 220 230 240 TVAYNDLESV KYAFEQFGDD IACIIVEPVA GNMGVVPPQP GFLEGLREVT EQNGALLIFD 250 260 270 280 290 300 EVMTGFRVAY NCGQGYYGVT PDLTCLGKVI GGGLPVGAYG GKAEIMRQVA PSGPIYQAGT 310 320 330 340 350 360 LSGNPLAMTA GYETLVQLTP ESYVEFERKA EMLEAGLRKA AEKHNIPHHI NRAGSMIGIF 370 380 390 400 410 420 FTDEQVINYD AAKSSNLEFF AAYYREMVEQ GVFLPPSQFE GLFLSTAHSD ADIEATIAAA EIAMSKLKA

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KBAB4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000903 Genomic DNA. Translation: ABY45465.1.
RefSeq	YP_001647093.1. NC_010184.1.
3D structure databases
ProteinModelPortal	A9VIT5.
SMR	A9VIT5. Positions 1-427.
ModBase	Search...
Protein-protein interaction databases
STRING	315730.BcerKBAB4_4306.
Proteomic databases
PRIDE	A9VIT5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABY45465; ABY45465; BcerKBAB4_4306.
GeneID	5844519.
KEGG	bwe:BcerKBAB4_4306.
PATRIC	19013278. VBIBacWei55973_4954.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0001.
HOGENOM	HOG000020210.
KO	K01845.
OMA	FNGNPIS.
ProtClustDB	PRK00062.
Enzyme and pathway databases
BioCyc	BWEI315730:GHRU-4422-MONOMER.
UniPathway	UPA00251; UER00317.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00713. hemL. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA2_BACWK

Accession

Primary (citable) accession number: A9VIT5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 1, 2009
Last sequence update:	February 5, 2008
Last modified:	May 29, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program