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A9VIT5

- GSA2_BACWK

UniProt

A9VIT5 - GSA2_BACWK

Protein

Glutamate-1-semialdehyde 2,1-aminomutase 2

Gene

hemL2

Organism
Bacillus weihenstephanensis (strain KBAB4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBWEI315730:GHRU-4422-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutase 2UniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSA 2UniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferase 2UniRule annotation
    Short name:
    GSA-AT 2UniRule annotation
    Gene namesi
    Name:hemL2UniRule annotation
    Ordered Locus Names:BcerKBAB4_4306
    OrganismiBacillus weihenstephanensis (strain KBAB4)
    Taxonomic identifieri315730 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000002154: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 429429Glutamate-1-semialdehyde 2,1-aminomutase 2PRO_0000382282Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei268 – 2681N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiA9VIT5.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi315730.BcerKBAB4_4306.

    Structurei

    3D structure databases

    ProteinModelPortaliA9VIT5.
    SMRiA9VIT5. Positions 1-427.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiRAIKPYP.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9VIT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKFDKSIAA FEEAQNLMPG GVNSPVRAFK SVGMNPLFME RGKGSKVYDI    50
    DGNEYIDYVL SWGPLIHGHA NDRVVEALKA VAEKGTSFGA PTEIENKLAQ 100
    LVIERVPSIE IVRMVNSGTE ATMSALRLAR GYTGRNKILK FIGCYHGHGD 150
    SLLIKAGSGV ATLGLPDSPG VPEGVAKNTI TVAYNDLESV KYAFEQFGDD 200
    IACIIVEPVA GNMGVVPPQP GFLEGLREVT EQNGALLIFD EVMTGFRVAY 250
    NCGQGYYGVT PDLTCLGKVI GGGLPVGAYG GKAEIMRQVA PSGPIYQAGT 300
    LSGNPLAMTA GYETLVQLTP ESYVEFERKA EMLEAGLRKA AEKHNIPHHI 350
    NRAGSMIGIF FTDEQVINYD AAKSSNLEFF AAYYREMVEQ GVFLPPSQFE 400
    GLFLSTAHSD ADIEATIAAA EIAMSKLKA 429
    Length:429
    Mass (Da):46,108
    Last modified:February 5, 2008 - v1
    Checksum:i566C7AC7B4D875DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000903 Genomic DNA. Translation: ABY45465.1.
    RefSeqiYP_001647093.1. NC_010184.1.

    Genome annotation databases

    EnsemblBacteriaiABY45465; ABY45465; BcerKBAB4_4306.
    GeneIDi5844519.
    KEGGibwe:BcerKBAB4_4306.
    PATRICi19013278. VBIBacWei55973_4954.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000903 Genomic DNA. Translation: ABY45465.1 .
    RefSeqi YP_001647093.1. NC_010184.1.

    3D structure databases

    ProteinModelPortali A9VIT5.
    SMRi A9VIT5. Positions 1-427.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315730.BcerKBAB4_4306.

    Proteomic databases

    PRIDEi A9VIT5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY45465 ; ABY45465 ; BcerKBAB4_4306 .
    GeneIDi 5844519.
    KEGGi bwe:BcerKBAB4_4306.
    PATRICi 19013278. VBIBacWei55973_4954.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi RAIKPYP.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci BWEI315730:GHRU-4422-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KBAB4.

    Entry informationi

    Entry nameiGSA2_BACWK
    AccessioniPrimary (citable) accession number: A9VIT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3