A9VID5 (A9VID5_BACWK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit 1 HAMAP MF_00444
EC=3.4.21.92 HAMAP MF_00444

Alternative name(s):
Endopeptidase Clp 1 HAMAP MF_00444

Gene names

Name:	clpP1 HAMAP MF_00444
Ordered Locus Names:	BcerKBAB4_2593

Organism

Bacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP] EMBL ABY43795.1

Taxonomic identifier

315730 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity HAMAP MF_00444.
Sequence similarities	Belongs to the peptidase S14 family. HAMAP MF_00444

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00444
Ligand	ATP-binding HAMAP MF_00444 Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease HAMAP MF_00444
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	98	1	By similarity HAMAP MF_00444
	Active site	123	1	By similarity HAMAP MF_00444

Sequences

	Sequence		Length	Mass (Da)
	A9VID5 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: E49D1477CEE5A15F	FASTA	193	21,262
	10 20 30 40 50 60 MSVIPYVIEQ TKLGERSYDI YSRLLKDRII MIGSEINDQV ASSVVAQLLF LEAEDAEKDI 70 80 90 100 110 120 FLYINSPGGS TTAGFAILDT MNLIKPDVQT LCMGFAASFG ALLLLAGAKG KRFALPNSEI 130 140 150 160 170 180 MIHQPLGGVK GQATEIEITA KRILKLKHDI NKIIAERTGQ PVEKVAHDTE RDYFMTAEEA 190 KEYGIVDAVI EKK

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000903 Genomic DNA. Translation: ABY43795.1.
RefSeq	YP_001645423.1. NC_010184.1.
3D structure databases
ProteinModelPortal	A9VID5.
SMR	A9VID5. Positions 3-193.
ModBase	Search...
Protein-protein interaction databases
STRING	A9VID5.
Protein family/group databases
MEROPS	S14.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000078072; EBBACP00000076006; EBBACG00000078063.
GeneID	5842805.
GenomeReviews	Gene locus BcerKBAB4_2593 in contig CP000903_GR.
KEGG	bwe:BcerKBAB4_2593.
PATRIC	19009789. VBIBacWei55973_3211.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000002046.
HOGENOM	HBG558421.
OMA	KHDINKI.
ProtClustDB	CLSK916804.
Family and domain databases
HAMAP	MF_00444. ClpP. [Tree]
InterPro	IPR023562. Pept_S14/S49. IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
KO	K01358.
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
TIGRFAMs	TIGR00493. ClpP. 1 hit.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A9VID5_BACWK

Accession

Primary (citable) accession number: A9VID5

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)