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A9VI99 (HEMH_BACWK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:BcerKBAB4_0990
OrganismBacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP]
Taxonomic identifier315730 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Ferrochelatase HAMAP MF_00323
PRO_1000116030

Sites

Metal binding1821Iron By similarity
Metal binding2631Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A9VI99 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 9A1E8A736C368DFD

FASTA31135,157
        10         20         30         40         50         60 
MKKKIGLLVM AYGTPYKEED IERYYTHIRR GRKPSPEMLE DLTGRYRAIG GISPLATITL 

        70         80         90        100        110        120 
EQAKKLETRL NEMQDEVEYH MYLGLKHIEP FIEDAVQAMH KDGIEDAIAL VLAPHYSTFS 

       130        140        150        160        170        180 
VKSYVGRAQE EAGKLGNLTI HGIDSWYKEP KFIQYWVDAV KGIYNGMSEA EREKAVLIVS 

       190        200        210        220        230        240 
AHSLPEKIIA LGDPYPDQLN ETADYIARGA EVANYAVGWQ SAGNTPDPWI GPDVQDLTRE 

       250        260        270        280        290        300 
LNEKYGYNSF VYAPVGFVAE HLEVLYDNDF ECKVVTDEIG AKYYRPEMPN ASDAFIDCLA 

       310 
DVVLKKKESV M

« Hide

References

[1]"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity."
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.
Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KBAB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000903 Genomic DNA. Translation: ABY42242.1.
RefSeqYP_001643870.1. NC_010184.1.

3D structure databases

ProteinModelPortalA9VI99.
SMRA9VI99. Positions 1-311.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9VI99.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000079570; EBBACP00000077504; EBBACG00000079561.
GeneID5841202.
GenomeReviewsGene locus BcerKBAB4_0990 in contig CP000903_GR.
KEGGbwe:BcerKBAB4_0990.
PATRIC19006490. VBIBacWei55973_1566.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000002085.
HOGENOMHBG697135.
OMASWYDEPK.
ProtClustDBPRK12435.

Enzyme and pathway databases

BioCycBWEI315730:BCERKBAB4_0990-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_BACWK
AccessionPrimary (citable) accession number: A9VI99
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 5, 2008
Last modified: January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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