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Reviewed, UniProtKB/Swiss-Prot A9VI98 (DCUP_BACWK)

Last modified November 3, 2009. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37
Gene names
Name: hemE
Ordered Locus Names: BcerKBAB4_0989
OrganismBacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP]
Taxonomic identifier315730 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

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Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

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Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_1000099973

Regions

Region27 – 315Substrate binding By similarity

Sites

Binding site461Substrate By similarity
Binding site761Substrate By similarity
Binding site1521Substrate By similarity
Binding site2071Substrate By similarity
Binding site3201Substrate By similarity
Site761Transition state stabilizer By similarity

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Sequences

Sequence LengthMass (Da)Tools
A9VI98-1 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: C28E130B006DCBA3

FASTA34839,318
        10         20         30         40         50         60 
MVRTINETFL KACRGERTEY VPAWYMRQAG RSQPEYRKIK EKYSLFEITH NPELCAYVTK 

        70         80         90        100        110        120 
LPVDQYNVDA AILYKDIMSP LPAIGVDVEI KSGIGPVIDS PIRSLQDVEK LGEINPEDDV 

       130        140        150        160        170        180 
PYILDTIRLL TTEMLDVPLI GFSGAPFTLA SYMIEGGPSR NYHNTKAFMY AEPKAWFALM 

       190        200        210        220        230        240 
DKLADMVITY LKAQINAGVK AVQIFDSWVG AVNVADYRIF IKPAMERIFA EVRPMGVPMI 

       250        260        270        280        290        300 
MHGVGAAHLV NEWHDLPLDV VGLDWRLPIE EARARGVHRA VQGNMDPSFL LAPWPVIEEH 

       310        320        330        340 
VKGILDQGMK QPGYIFNLGH GVFPEVNPDT LKRLTTFIHE YSKEQLAK

« Hide

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References

[1]"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity."
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.
Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000903 Genomic DNA. Translation: ABY42241.1.
RefSeqYP_001643869.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID5841201.
GenomeReviewsGene locus BcerKBAB4_0989 in contig CP000903_GR.
KEGGbwe:BcerKBAB4_0989.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAVFTKGGG.

Family and domain databases

HAMAPMF_00218.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
ProDomPD003225. Uro_decarbxyls. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01464. hemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDCUP_BACWK
AccessionPrimary (citable) accession number: A9VI98
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 5, 2008
Last modified: November 3, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents