A9VHW1 (AROE_BACWK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	BcerKBAB4_4185

Organism

Bacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP]

Taxonomic identifier

315730 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000100104
Regions
	Nucleotide binding	127 – 131	5	NADP By similarity
Sites
	Active site	66	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	A9VHW1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 9B3035945DAAE8FF	FASTA	277	30,295
	10 20 30 40 50 60 MKQLYGVIGN PIGHSLSPVM HNDAFEHLNM DAHYLAFLVE EEALGEAVKG LKALGISGFN 70 80 90 100 110 120 VTTPHKVAIM EYLDEIAPLA RQIGAVNTVV HRDGKLIGYN TDGIGFVRAL QSISEDPLQE 130 140 150 160 170 180 KRILLIGAGG ASRAIYFSLA DVGVKEIDIA NRTRDKAKNL ISGCMENVNS HALSLECAAE 190 200 210 220 230 240 NQGEYDIIIQ TTTIGMHPHV EYTPLEIRSL KQGTIVSDII YNPFETKILG DAKEQGAIIQ 250 260 270 NGIDMFVYQG ALAFEMWTGC VPNIDRMKQL VMRELGG

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KBAB4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000903 Genomic DNA. Translation: ABY45346.1.
RefSeq	YP_001646974.1. NC_010184.1.
3D structure databases
ProteinModelPortal	A9VHW1.
SMR	A9VHW1. Positions 1-275.
ModBase	Search...
Protein-protein interaction databases
STRING	A9VHW1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000081934; EBBACP00000079868; EBBACG00000081925.
GeneID	5844398.
GenomeReviews	Gene locus BcerKBAB4_4185 in contig CP000903_GR.
KEGG	bwe:BcerKBAB4_4185.
PATRIC	19013034. VBIBacWei55973_4832.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000000826.
HOGENOM	HBG553408.
OMA	FEMWTGC.
ProtClustDB	PRK00258.
Enzyme and pathway databases
BioCyc	BWEI315730:BCERKBAB4_4185-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_BACWK

Accession

Primary (citable) accession number: A9VHW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program