A9VHP8 (KYNB_BACWK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
EC=3.5.1.9

Alternative name(s):
N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	BcerKBAB4_2558

Organism

Bacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP]

Taxonomic identifier

315730 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB formamidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Kynurenine formamidase		PRO_0000362094

Sequences

	Sequence		Length	Mass (Da)
	A9VHP8 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: BA230177700C5AA8	FASTA	209	23,075
	10 20 30 40 50 60 MKTSQWIDIS QPLNNDIATW PGDTPFSYEV SWSKENSGSV NVGKLTMSIH TGTHIDAPFH 70 80 90 100 110 120 FDNDGKKVLD LDIQVYVGPA RIIDVSNLES IGKKELENFH LEGVERLLLR TSSHGKANEF 130 140 150 160 170 180 PDVIPHLRAD IAAFLSEKGI RLIGVDVPSV DPLDDKELAA HHQLFKHGIH ILENVVLDHV 190 200 VDGDYELIAL PLALTDADGS PVRAVIRPI

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KBAB4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000903 Genomic DNA. Translation: ABY43762.1.
RefSeq	YP_001645390.1. NC_010184.1.
3D structure databases
ProteinModelPortal	A9VHP8.
ModBase	Search...
Protein-protein interaction databases
STRING	A9VHP8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000081375; EBBACP00000079309; EBBACG00000081366.
GeneID	5842771.
GenomeReviews	Gene locus BcerKBAB4_2558 in contig CP000903_GR.
KEGG	bwe:BcerKBAB4_2558.
PATRIC	19009721. VBIBacWei55973_3177.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000003083.
HOGENOM	HBG686791.
OMA	HTSKWPL.
ProtClustDB	CLSK904617.
Enzyme and pathway databases
BioCyc	BWEI315730:BCERKBAB4_2558-MONOMER.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
KO	K07130.
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. Trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_BACWK

Accession

Primary (citable) accession number: A9VHP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program