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Protein

Serine-protein kinase RsbW

Gene

rsbW

Organism
Bacillus weihenstephanensis (strain KBAB4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-protein kinase RsbWUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Anti-sigma-B factorUniRule annotation
Sigma-B negative effector RsbWUniRule annotation
Gene namesi
Name:rsbWUniRule annotation
Ordered Locus Names:BcerKBAB4_0902
OrganismiBacillus weihenstephanensis (strain KBAB4)
Taxonomic identifieri315730 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002154 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001308181 – 160Serine-protein kinase RsbWAdd BLAST160

Interactioni

Protein-protein interaction databases

STRINGi315730.BcerKBAB4_0902.

Structurei

3D structure databases

ProteinModelPortaliA9VHG0.
SMRiA9VHG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2172. LUCA.
HOGENOMiHOG000269932.
KOiK04757.
OMAiKMGFSYE.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00638. Anti_sigma_B. 1 hit.
InterProiIPR003594. HATPase_C.
IPR010193. RsbW.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01924. rsbW_low_gc. 1 hit.

Sequencei

Sequence statusi: Complete.

A9VHG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEKFEKIEM KIPAKAEYVA IIRLTMAGVA NRMGFAYDDM EDMKIAISEA
60 70 80 90 100
CTNIVQHAYK EDVGEITIVF GLYEDRLEIM VADNGVSFNF STLKSKVGPY
110 120 130 140 150
DINKPVEHLP ENGLGLYLIN TLMDDIQIMH DEGMTVLMTK YIQREQVEND
160
GNPISTYRSY
Length:160
Mass (Da):18,247
Last modified:February 5, 2008 - v1
Checksum:iDE23DD4F05FC75C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000903 Genomic DNA. Translation: ABY42155.1.
RefSeqiWP_012260477.1. NC_010184.1.

Genome annotation databases

EnsemblBacteriaiABY42155; ABY42155; BcerKBAB4_0902.
KEGGibwe:BcerKBAB4_0902.
PATRICi19006310. VBIBacWei55973_1476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000903 Genomic DNA. Translation: ABY42155.1.
RefSeqiWP_012260477.1. NC_010184.1.

3D structure databases

ProteinModelPortaliA9VHG0.
SMRiA9VHG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315730.BcerKBAB4_0902.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY42155; ABY42155; BcerKBAB4_0902.
KEGGibwe:BcerKBAB4_0902.
PATRICi19006310. VBIBacWei55973_1476.

Phylogenomic databases

eggNOGiCOG2172. LUCA.
HOGENOMiHOG000269932.
KOiK04757.
OMAiKMGFSYE.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00638. Anti_sigma_B. 1 hit.
InterProiIPR003594. HATPase_C.
IPR010193. RsbW.
[Graphical view]
PfamiPF13581. HATPase_c_2. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR01924. rsbW_low_gc. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRSBW_BACWK
AccessioniPrimary (citable) accession number: A9VHG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.