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A9VH19 (AROK_BACWK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Shikimate kinase
Short name=SK
EC=2.7.1.71
Gene names
Name:aroK
Ordered Locus Names:BcerKBAB4_4089
OrganismBacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP]
Taxonomic identifier315730 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity. HAMAP MF_00109

Catalytic activity

ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP MF_00109

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00109

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP MF_00109

Subunit structure

Monomer By similarity. HAMAP MF_00109

Subcellular location

Cytoplasm By similarity HAMAP MF_00109.

Sequence similarities

Belongs to the shikimate kinase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

shikimate kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 165165Shikimate kinase HAMAP MF_00109
PRO_1000094375

Regions

Nucleotide binding11 – 166ATP By similarity

Sites

Metal binding151Magnesium By similarity
Binding site331Substrate By similarity
Binding site571Substrate By similarity
Binding site781Substrate; via amide nitrogen By similarity
Binding site1161ATP By similarity
Binding site1341Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A9VH19 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 18790B97CB66410B

FASTA16519,202
        10         20         30         40         50         60 
MKSIYITGYM GAGKTTIGKV LSKELHMDVV DTDQKIEEKQ EKAIRDIFAE EGEMAFREYE 

        70         80         90        100        110        120 
SEMVRSLPVQ NVIITTGGGI IERAENRKWM KENGTVVYLY CDPHVIAERL REDTTRPLFQ 

       130        140        150        160 
KKDIDAFITK FESRRAYYEE ADIHIDTTNK SVKQIMNELK QKINE

« Hide

References

[1]"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity."
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.
Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KBAB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000903 Genomic DNA. Translation: ABY45251.1.
RefSeqYP_001646879.1. NC_010184.1.

3D structure databases

ProteinModelPortalA9VH19.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9VH19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000080668; EBBACP00000078602; EBBACG00000080659.
GeneID5844301.
GenomeReviewsGene locus BcerKBAB4_4089 in contig CP000903_GR.
KEGGbwe:BcerKBAB4_4089.
PATRIC19012823. VBIBacWei55973_4728.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000003023.
HOGENOMHBG335815.
OMAMIISERV.
ProtClustDBPRK00131.

Enzyme and pathway databases

BioCycBWEI315730:BCERKBAB4_4089-MONOMER.

Family and domain databases

HAMAPMF_00109. Shikimate_kinase.
[Tree]
InterProIPR000623. Shikimate_kinase.
[Graphical view]
KOK00891.
PfamPF01202. SKI. 1 hit.
[Graphical view]
PRINTSPR01100. SHIKIMTKNASE.
PROSITEPS01128. SHIKIMATE_KINASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROK_BACWK
AccessionPrimary (citable) accession number: A9VH19
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 5, 2008
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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