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Protein

Ribonuclease Z

Gene

rnz

Organism
Bacillus weihenstephanensis (strain KBAB4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi63 – 631Zinc 1; catalyticUniRule annotation
Metal bindingi65 – 651Zinc 1; catalyticUniRule annotation
Active sitei67 – 671Proton acceptorUniRule annotation
Metal bindingi67 – 671Zinc 2; catalyticUniRule annotation
Metal bindingi68 – 681Zinc 2; catalyticUniRule annotation
Metal bindingi141 – 1411Zinc 1; catalyticUniRule annotation
Metal bindingi212 – 2121Zinc 1; catalyticUniRule annotation
Metal bindingi212 – 2121Zinc 2; catalyticUniRule annotation
Metal bindingi270 – 2701Zinc 2; catalyticUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBWEI315730:GHRU-4088-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:BcerKBAB4_3973
OrganismiBacillus weihenstephanensis (strain KBAB4)
Taxonomic identifieri315730 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002154 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Ribonuclease ZPRO_1000187936Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi315730.BcerKBAB4_3973.

Structurei

3D structure databases

ProteinModelPortaliA9VG79.
SMRiA9VG79. Positions 1-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105IES. Bacteria.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiSYAFCSD.
OrthoDBiEOG61P6TK.

Family and domain databases

Gene3Di3.60.15.10. 2 hits.
HAMAPiMF_01818. RNase_Z_BN.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
PF12706. Lactamase_B_2. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

A9VG79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFVFLGTGA GVPSKGRNVS AIALQLLEER GQTWLFDCGE ATQHQILHTS
60 70 80 90 100
VRPRRIEKIF ITHLHGDHIF GLPGLLGSRS FQGGTTKLTV YGPKGIKQFI
110 120 130 140 150
EVALLVSTTH VKYPLEIVEI TEEGIVFEDN EFCVETKRLS HGIECFGYRI
160 170 180 190 200
VEKDIQGALL VDKLLGMGVK PGPVFKRLKD GEVVELENGT VLDGKDFIGP
210 220 230 240 250
PQKGRVITIL GDTRYCEASR ELAQDADVLV HEATFAAEDE QQAYDYFHST
260 270 280 290 300
SKQAASIALQ ANAKRLILTH ISSRYQGDTY KELLKEAREL FSNTEIATDL

KSFPVER
Length:307
Mass (Da):34,149
Last modified:February 5, 2008 - v1
Checksum:i22485316E32A67C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000903 Genomic DNA. Translation: ABY45139.1.
RefSeqiWP_002014952.1. NC_010184.1.

Genome annotation databases

EnsemblBacteriaiABY45139; ABY45139; BcerKBAB4_3973.
GeneIDi22938291.
KEGGibwe:BcerKBAB4_3973.
PATRICi19012593. VBIBacWei55973_4613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000903 Genomic DNA. Translation: ABY45139.1.
RefSeqiWP_002014952.1. NC_010184.1.

3D structure databases

ProteinModelPortaliA9VG79.
SMRiA9VG79. Positions 1-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315730.BcerKBAB4_3973.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY45139; ABY45139; BcerKBAB4_3973.
GeneIDi22938291.
KEGGibwe:BcerKBAB4_3973.
PATRICi19012593. VBIBacWei55973_4613.

Phylogenomic databases

eggNOGiENOG4105IES. Bacteria.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiSYAFCSD.
OrthoDBiEOG61P6TK.

Enzyme and pathway databases

BioCyciBWEI315730:GHRU-4088-MONOMER.

Family and domain databases

Gene3Di3.60.15.10. 2 hits.
HAMAPiMF_01818. RNase_Z_BN.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
PF12706. Lactamase_B_2. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KBAB4.

Entry informationi

Entry nameiRNZ_BACWK
AccessioniPrimary (citable) accession number: A9VG79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 5, 2008
Last modified: May 11, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.