Reviewed, UniProtKB/Swiss-Prot A9VG72 (ARGC_BACWK)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	BcerKBAB4_3965

Organism

Bacillus weihenstephanensis (strain KBAB4) [Complete proteome] [HAMAP]

Taxonomic identifier

315730 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm By similarity HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000096714
Sites
	Active site	149	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9VG72-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 05033C95BCBB485A	FASTA	345	38,536
	10 20 30 40 50 60 MKVAIIGATG YGGIELIRLL EQHPYFSIAS LHSFSQVGEF ITNVYPHFRN VLVHTLQEID 70 80 90 100 110 120 AEKIEKEAEI VFLATPAGVS AELTPKLLAV GLKVIDLSGD FRMIDPSSYE LWYKRPAAQE 130 140 150 160 170 180 ELLRKAVYGL SEWKRPEIQN ANLIANPGCF ATAALLAVAP LVRSGIIEEA SIIIDAKSGV 190 200 210 220 230 240 SGAGKTPTTM THFPELYDNL HIYKVNQHQH VPEIEQMLTE WNRETKPITF STHLIPISRG 250 260 270 280 290 300 IMITLYAKVK EEMKIEQLQK LYEETYEYSA FVRVRSQGEF PSPKEVRGSN YCDIGIAYDE 310 320 330 340 RTERVTVVSV IDNMMKGAAG QAVQNANLLA GLEETTGLQH MPLYP

References

[1]

"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity." Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A. Chem. Biol. Interact. 171:236-249(2008) [PubMed: 17434157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000903 Genomic DNA. Translation: ABY45132.1.
RefSeq	YP_001646760.1.
3D structure databases
SMR	A9VG72. Positions 1-345.
ModBase	Search...
Genome annotation databases
GeneID	5844177.
GenomeReviews	Gene locus BcerKBAB4_3965 in contig CP000903_GR.
KEGG	bwe:BcerKBAB4_3965.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG294213.
OMA	VCRIAVH.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BACWK

Accession

Primary (citable) accession number: A9VG72

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 5, 2008
Last modified:	February 9, 2010
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)