ID   A9VD43_MONBE            Unreviewed;       619 AA.
AC   A9VD43;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   13-SEP-2023, entry version 56.
DE   RecName: Full=SH2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=MONBRDRAFT_30131 {ECO:0000313|EMBL:EDQ84576.1};
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ84576.1, ECO:0000313|Proteomes:UP000001357};
RN   [1] {ECO:0000313|EMBL:EDQ84576.1, ECO:0000313|Proteomes:UP000001357}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT   metazoans.";
RL   Nature 451:783-788(2008).
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DR   EMBL; CH991584; EDQ84576.1; -; Genomic_DNA.
DR   RefSeq; XP_001750603.1; XM_001750551.1.
DR   AlphaFoldDB; A9VD43; -.
DR   EnsemblProtists; EDQ84576; EDQ84576; MONBRDRAFT_30131.
DR   GeneID; 5895844; -.
DR   KEGG; mbr:MONBRDRAFT_30131; -.
DR   InParanoid; A9VD43; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035591; F:signaling adaptor activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   CDD; cd00173; SH2; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR046355; Gab1-4-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR45960; GRB2-ASSOCIATED-BINDING PROTEIN; 1.
DR   PANTHER; PTHR45960:SF2; PROTEIN DAUGHTER OF SEVENLESS; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00017; SH2; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001357};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        26..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        53..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          76..184
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          265..362
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   REGION          191..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          564..619
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   619 AA;  67323 MW;  3875F54C007566EF CRC64;
     MGWLCAGPAV IRESPGRRQP GRFDSVYVYV YVCVCVVCVC VSLSPFWNFS LSLSLSLSLS
     SLFSLSLVFF FSMSSDVVRN GWLIKSPPPG ALKGWKRRFF RFLRATNAGK ARMEYYVDPG
     DVQRSMPKGI INLSDCTTVE EGPSEERRMK FFFRIVLPQR TYVLCAENRL ERDDWIKDLR
     EELFAKAVAT PPAATPAPTP ALPSNPASPA HSSRNSASSG SQLPGHSVRQ PPPTPTPFQG
     QPASSPSKDH GASRPQPKPV GPDNWLYGKI SRQMAEDLLA DYGHQQGMFI VRESSQRGSH
     AVTVVHQGRV IHHLVTQTAG GLYLLNNQPC GSCASLEEVI DFLGTPHSTP VRWKSALIIS
     PLDFDKNLLS GGANKRQSTA LPAYTSLPLQ SETEAPPSPS AATSVPASPA ACLAASLPRP
     TNRPSHSEQV YSCQLCATDG ARRLGITANM RCDVRVIGRD FAVLNPANSV ELASWNVIGV
     QSVCATPKQF EFVIVGSQPN PGHFCLETTE SQAILAALKP FLPPSAIRPS NSANVVEPGF
     ELMSSALNDD DSDDERAVQD YQWDNHGVEE PPAPALPSRT VSAEPNNAAV PPLPRRDAKR
     QYPGLPTRRR QEVGLQPRG
//